Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant cancer with complex genomic variations, and no targetable genomic lesions have been found yet. Super‐enhancers (SEs) have been found to contribute to the continuous and robust oncogenic transcription. Here, histone H3 lysine 27 acetylatio...

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Detalles Bibliográficos
Autores principales: Huang, Chen‐Song, You, Xinru, Dai, Chunlei, Xu, Qiong‐Cong, Li, Fuxi, Wang, Li, Huang, Xi‐Tai, Wang, Jie‐Qin, Li, Shi‐Jin, Gao, Zhuoxing, Wu, Jun, Yin, Xiao‐Yu, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140991/
https://www.ncbi.nlm.nih.gov/pubmed/32274304
http://dx.doi.org/10.1002/advs.201902926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140991/
https://www.ncbi.nlm.nih.gov/pubmed/32274304
http://dx.doi.org/10.1002/advs.201902926

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