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Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise

Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystem...

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Autores principales: Liu, Heng, Yang, Youyuan, Liu, Yu, Pan, Jingjing, Wang, Junqing, Man, Fengyuan, Zhang, Weiguo, Liu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141020/
https://www.ncbi.nlm.nih.gov/pubmed/32274309
http://dx.doi.org/10.1002/advs.201903129
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author Liu, Heng
Yang, Youyuan
Liu, Yu
Pan, Jingjing
Wang, Junqing
Man, Fengyuan
Zhang, Weiguo
Liu, Gang
author_facet Liu, Heng
Yang, Youyuan
Liu, Yu
Pan, Jingjing
Wang, Junqing
Man, Fengyuan
Zhang, Weiguo
Liu, Gang
author_sort Liu, Heng
collection PubMed
description Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystems, possessing fascinating physicochemical properties and playing significant physiological roles. The multifunctionality together with intrinsic biocompatibility renders bioinspired melanin‐like nanomaterials considerably promising as a versatile and powerful nanoplatform with broad bioapplication prospects. This panoramic Review starts with an overview of the fundamental physicochemical properties, preparation methods, and polymerization mechanisms of melanins. A systematical and well‐bedded description of recent advancements of melanin‐like nanomaterials regarding diverse biomedical applications is then given, mainly focusing on biological imaging, photothermal therapy, drug delivery for tumor treatment, and other emerging biomedicine‐related implementations. Finally, current challenges toward clinical translation with an emphasis on innovative design strategies and future striving directions are rationally discussed. This comprehensive and detailed Review provides a deep understanding of the current research status of melanin‐like nanomaterials and is expected to motivate further optimization of the design of novel tailorable and marketable multifunctional nanoplatforms in biomedicine.
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spelling pubmed-71410202020-04-09 Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise Liu, Heng Yang, Youyuan Liu, Yu Pan, Jingjing Wang, Junqing Man, Fengyuan Zhang, Weiguo Liu, Gang Adv Sci (Weinh) Reviews Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystems, possessing fascinating physicochemical properties and playing significant physiological roles. The multifunctionality together with intrinsic biocompatibility renders bioinspired melanin‐like nanomaterials considerably promising as a versatile and powerful nanoplatform with broad bioapplication prospects. This panoramic Review starts with an overview of the fundamental physicochemical properties, preparation methods, and polymerization mechanisms of melanins. A systematical and well‐bedded description of recent advancements of melanin‐like nanomaterials regarding diverse biomedical applications is then given, mainly focusing on biological imaging, photothermal therapy, drug delivery for tumor treatment, and other emerging biomedicine‐related implementations. Finally, current challenges toward clinical translation with an emphasis on innovative design strategies and future striving directions are rationally discussed. This comprehensive and detailed Review provides a deep understanding of the current research status of melanin‐like nanomaterials and is expected to motivate further optimization of the design of novel tailorable and marketable multifunctional nanoplatforms in biomedicine. John Wiley and Sons Inc. 2020-02-07 /pmc/articles/PMC7141020/ /pubmed/32274309 http://dx.doi.org/10.1002/advs.201903129 Text en © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Liu, Heng
Yang, Youyuan
Liu, Yu
Pan, Jingjing
Wang, Junqing
Man, Fengyuan
Zhang, Weiguo
Liu, Gang
Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
title Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
title_full Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
title_fullStr Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
title_full_unstemmed Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
title_short Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
title_sort melanin‐like nanomaterials for advanced biomedical applications: a versatile platform with extraordinary promise
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141020/
https://www.ncbi.nlm.nih.gov/pubmed/32274309
http://dx.doi.org/10.1002/advs.201903129
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