Cargando…
Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise
Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystem...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141020/ https://www.ncbi.nlm.nih.gov/pubmed/32274309 http://dx.doi.org/10.1002/advs.201903129 |
_version_ | 1783519105907687424 |
---|---|
author | Liu, Heng Yang, Youyuan Liu, Yu Pan, Jingjing Wang, Junqing Man, Fengyuan Zhang, Weiguo Liu, Gang |
author_facet | Liu, Heng Yang, Youyuan Liu, Yu Pan, Jingjing Wang, Junqing Man, Fengyuan Zhang, Weiguo Liu, Gang |
author_sort | Liu, Heng |
collection | PubMed |
description | Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystems, possessing fascinating physicochemical properties and playing significant physiological roles. The multifunctionality together with intrinsic biocompatibility renders bioinspired melanin‐like nanomaterials considerably promising as a versatile and powerful nanoplatform with broad bioapplication prospects. This panoramic Review starts with an overview of the fundamental physicochemical properties, preparation methods, and polymerization mechanisms of melanins. A systematical and well‐bedded description of recent advancements of melanin‐like nanomaterials regarding diverse biomedical applications is then given, mainly focusing on biological imaging, photothermal therapy, drug delivery for tumor treatment, and other emerging biomedicine‐related implementations. Finally, current challenges toward clinical translation with an emphasis on innovative design strategies and future striving directions are rationally discussed. This comprehensive and detailed Review provides a deep understanding of the current research status of melanin‐like nanomaterials and is expected to motivate further optimization of the design of novel tailorable and marketable multifunctional nanoplatforms in biomedicine. |
format | Online Article Text |
id | pubmed-7141020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71410202020-04-09 Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise Liu, Heng Yang, Youyuan Liu, Yu Pan, Jingjing Wang, Junqing Man, Fengyuan Zhang, Weiguo Liu, Gang Adv Sci (Weinh) Reviews Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystems, possessing fascinating physicochemical properties and playing significant physiological roles. The multifunctionality together with intrinsic biocompatibility renders bioinspired melanin‐like nanomaterials considerably promising as a versatile and powerful nanoplatform with broad bioapplication prospects. This panoramic Review starts with an overview of the fundamental physicochemical properties, preparation methods, and polymerization mechanisms of melanins. A systematical and well‐bedded description of recent advancements of melanin‐like nanomaterials regarding diverse biomedical applications is then given, mainly focusing on biological imaging, photothermal therapy, drug delivery for tumor treatment, and other emerging biomedicine‐related implementations. Finally, current challenges toward clinical translation with an emphasis on innovative design strategies and future striving directions are rationally discussed. This comprehensive and detailed Review provides a deep understanding of the current research status of melanin‐like nanomaterials and is expected to motivate further optimization of the design of novel tailorable and marketable multifunctional nanoplatforms in biomedicine. John Wiley and Sons Inc. 2020-02-07 /pmc/articles/PMC7141020/ /pubmed/32274309 http://dx.doi.org/10.1002/advs.201903129 Text en © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Liu, Heng Yang, Youyuan Liu, Yu Pan, Jingjing Wang, Junqing Man, Fengyuan Zhang, Weiguo Liu, Gang Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise |
title | Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise |
title_full | Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise |
title_fullStr | Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise |
title_full_unstemmed | Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise |
title_short | Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise |
title_sort | melanin‐like nanomaterials for advanced biomedical applications: a versatile platform with extraordinary promise |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141020/ https://www.ncbi.nlm.nih.gov/pubmed/32274309 http://dx.doi.org/10.1002/advs.201903129 |
work_keys_str_mv | AT liuheng melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT yangyouyuan melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT liuyu melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT panjingjing melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT wangjunqing melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT manfengyuan melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT zhangweiguo melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise AT liugang melaninlikenanomaterialsforadvancedbiomedicalapplicationsaversatileplatformwithextraordinarypromise |