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Differences in the Outcome of Patients with COPD according to Body Mass Index
Background: In chronic obstructive pulmonary disease (COPD), the “obesity paradox” is a phenomenon without a clear cause. The objective is to analyze the complications of COPD patients according to their body mass index (BMI). Methods: An observational study with a six-year prospective follow-up of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141195/ https://www.ncbi.nlm.nih.gov/pubmed/32151054 http://dx.doi.org/10.3390/jcm9030710 |
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author | Ji, Zichen de Miguel-Díez, Javier Castro-Riera, Christian Reynaldo Bellón-Cano, José María Gallo-González, Virginia Girón-Matute, Walther Iván Jiménez-García, Rodrigo López-de Andrés, Ana Moya-Álvarez, Virginia Puente-Maestu, Luis Hernández-Vázquez, Julio |
author_facet | Ji, Zichen de Miguel-Díez, Javier Castro-Riera, Christian Reynaldo Bellón-Cano, José María Gallo-González, Virginia Girón-Matute, Walther Iván Jiménez-García, Rodrigo López-de Andrés, Ana Moya-Álvarez, Virginia Puente-Maestu, Luis Hernández-Vázquez, Julio |
author_sort | Ji, Zichen |
collection | PubMed |
description | Background: In chronic obstructive pulmonary disease (COPD), the “obesity paradox” is a phenomenon without a clear cause. The objective is to analyze the complications of COPD patients according to their body mass index (BMI). Methods: An observational study with a six-year prospective follow-up of 273 COPD patients who attended a spirometry test in 2011. Survival and acute events were analyzed according to the BMI quartiles. Results: A total of 273 patients were included. BMI quartiles were ≤24.23; 24.24–27.69; 27.70–31.25; ≥31.26. During the follow-up, 93 patients died. No differences were found in exacerbations, pneumonia, emergency visits, hospital admissions or income in a critical unit. Survival was lower in the quartile 1 of BMI with respect to each of the 2–4 quartiles (p-value 0.019, 0.013, and 0.004, respectively). Advanced age (hazard ratio, HR 1.06; 95% confidence interval, CI 1.03–1.09), low pulmonary function (HR 0.93; 95% CI 0.86–0.99), exacerbator with chronic bronchitis phenotype (HR 1.76; 95% CI 1.01–3.06), high Charlson (HR 1.32, 95% CI 1.18–1.49), and the quartile 1 of BMI (HR 1.99, 95% CI 1.08–3.69) were identified as risk factors independently associated with mortality. Conclusions: In COPD, low BMI conditions a lower survival, although not for having more acute events. |
format | Online Article Text |
id | pubmed-7141195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71411952020-04-10 Differences in the Outcome of Patients with COPD according to Body Mass Index Ji, Zichen de Miguel-Díez, Javier Castro-Riera, Christian Reynaldo Bellón-Cano, José María Gallo-González, Virginia Girón-Matute, Walther Iván Jiménez-García, Rodrigo López-de Andrés, Ana Moya-Álvarez, Virginia Puente-Maestu, Luis Hernández-Vázquez, Julio J Clin Med Article Background: In chronic obstructive pulmonary disease (COPD), the “obesity paradox” is a phenomenon without a clear cause. The objective is to analyze the complications of COPD patients according to their body mass index (BMI). Methods: An observational study with a six-year prospective follow-up of 273 COPD patients who attended a spirometry test in 2011. Survival and acute events were analyzed according to the BMI quartiles. Results: A total of 273 patients were included. BMI quartiles were ≤24.23; 24.24–27.69; 27.70–31.25; ≥31.26. During the follow-up, 93 patients died. No differences were found in exacerbations, pneumonia, emergency visits, hospital admissions or income in a critical unit. Survival was lower in the quartile 1 of BMI with respect to each of the 2–4 quartiles (p-value 0.019, 0.013, and 0.004, respectively). Advanced age (hazard ratio, HR 1.06; 95% confidence interval, CI 1.03–1.09), low pulmonary function (HR 0.93; 95% CI 0.86–0.99), exacerbator with chronic bronchitis phenotype (HR 1.76; 95% CI 1.01–3.06), high Charlson (HR 1.32, 95% CI 1.18–1.49), and the quartile 1 of BMI (HR 1.99, 95% CI 1.08–3.69) were identified as risk factors independently associated with mortality. Conclusions: In COPD, low BMI conditions a lower survival, although not for having more acute events. MDPI 2020-03-05 /pmc/articles/PMC7141195/ /pubmed/32151054 http://dx.doi.org/10.3390/jcm9030710 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ji, Zichen de Miguel-Díez, Javier Castro-Riera, Christian Reynaldo Bellón-Cano, José María Gallo-González, Virginia Girón-Matute, Walther Iván Jiménez-García, Rodrigo López-de Andrés, Ana Moya-Álvarez, Virginia Puente-Maestu, Luis Hernández-Vázquez, Julio Differences in the Outcome of Patients with COPD according to Body Mass Index |
title | Differences in the Outcome of Patients with COPD according to Body Mass Index |
title_full | Differences in the Outcome of Patients with COPD according to Body Mass Index |
title_fullStr | Differences in the Outcome of Patients with COPD according to Body Mass Index |
title_full_unstemmed | Differences in the Outcome of Patients with COPD according to Body Mass Index |
title_short | Differences in the Outcome of Patients with COPD according to Body Mass Index |
title_sort | differences in the outcome of patients with copd according to body mass index |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141195/ https://www.ncbi.nlm.nih.gov/pubmed/32151054 http://dx.doi.org/10.3390/jcm9030710 |
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