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Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission

A number of bioactive components of diet are indicated as potential dietary factors for the management of ulcerative colitis, while the recent study conducted in an animal model revealed that proanthocyanidins from grape seeds exert a broadly positive impact. The aim of the study was to verify the i...

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Autores principales: Głąbska, Dominika, Guzek, Dominika, Gałązka, Karolina, Lech, Gustaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141196/
https://www.ncbi.nlm.nih.gov/pubmed/32178368
http://dx.doi.org/10.3390/jcm9030771
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author Głąbska, Dominika
Guzek, Dominika
Gałązka, Karolina
Lech, Gustaw
author_facet Głąbska, Dominika
Guzek, Dominika
Gałązka, Karolina
Lech, Gustaw
author_sort Głąbska, Dominika
collection PubMed
description A number of bioactive components of diet are indicated as potential dietary factors for the management of ulcerative colitis, while the recent study conducted in an animal model revealed that proanthocyanidins from grape seeds exert a broadly positive impact. The aim of the study was to verify the influence of dietary proanthocyanidins intake on the symptoms of ulcerative colitis in remission in human subjects. The study was conducted in a group of 55 participants (19 males, 36 females) in remission of ulcerative colitis confirmed based on both the Mayo Scoring system and Rachmilewitz index. Their habitual dietary intake of proanthocyanidins and intake recalculated per 1000 kcal of diet was assessed and it was verified whether they are associated with symptoms of ulcerative colitis. The energy value of diet and intake of other nutrients were analyzed as potential interfering factors. Participants declaring the presence of mucus in their stool compared with other participants were characterized by higher proanthocyanidins intake (142 vs. 75 mg; p = 0.0441) and intake per 1000 kcal (91 vs. 37 mg/1000 kcal; p = 0.0092), while for no other nutrient such association was stated. Participants declaring constipation compared with other participants were characterized by higher proanthocyanidins intake (214 vs. 82 mg; p = 0.0289) and intake per 1000 kcal (118 vs. 41 mg/1000 kcal; p = 0.0194). Similar association for constipation was observed in the case of energy value of diet and protein intake, but only for proanthocyanidins intake, it was confirmed in the logistic regression model (p = 0.0183; OR = 1.01; 95% CI 1.00–1.02). The positive influence of habitual dietary intake of proanthocyanidins was confirmed in the studied group of patients with ulcerative colitis in remission, as this intake may have increased the production of mucus, which is beneficial for intestinal healing, and may have reduced the frequency of bowel movements. However, further experimental human studies are necessary to confirm the potential influence of proanthocyanidins intake in patients with ulcerative colitis in remission.
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spelling pubmed-71411962020-04-10 Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission Głąbska, Dominika Guzek, Dominika Gałązka, Karolina Lech, Gustaw J Clin Med Article A number of bioactive components of diet are indicated as potential dietary factors for the management of ulcerative colitis, while the recent study conducted in an animal model revealed that proanthocyanidins from grape seeds exert a broadly positive impact. The aim of the study was to verify the influence of dietary proanthocyanidins intake on the symptoms of ulcerative colitis in remission in human subjects. The study was conducted in a group of 55 participants (19 males, 36 females) in remission of ulcerative colitis confirmed based on both the Mayo Scoring system and Rachmilewitz index. Their habitual dietary intake of proanthocyanidins and intake recalculated per 1000 kcal of diet was assessed and it was verified whether they are associated with symptoms of ulcerative colitis. The energy value of diet and intake of other nutrients were analyzed as potential interfering factors. Participants declaring the presence of mucus in their stool compared with other participants were characterized by higher proanthocyanidins intake (142 vs. 75 mg; p = 0.0441) and intake per 1000 kcal (91 vs. 37 mg/1000 kcal; p = 0.0092), while for no other nutrient such association was stated. Participants declaring constipation compared with other participants were characterized by higher proanthocyanidins intake (214 vs. 82 mg; p = 0.0289) and intake per 1000 kcal (118 vs. 41 mg/1000 kcal; p = 0.0194). Similar association for constipation was observed in the case of energy value of diet and protein intake, but only for proanthocyanidins intake, it was confirmed in the logistic regression model (p = 0.0183; OR = 1.01; 95% CI 1.00–1.02). The positive influence of habitual dietary intake of proanthocyanidins was confirmed in the studied group of patients with ulcerative colitis in remission, as this intake may have increased the production of mucus, which is beneficial for intestinal healing, and may have reduced the frequency of bowel movements. However, further experimental human studies are necessary to confirm the potential influence of proanthocyanidins intake in patients with ulcerative colitis in remission. MDPI 2020-03-12 /pmc/articles/PMC7141196/ /pubmed/32178368 http://dx.doi.org/10.3390/jcm9030771 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Głąbska, Dominika
Guzek, Dominika
Gałązka, Karolina
Lech, Gustaw
Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission
title Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission
title_full Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission
title_fullStr Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission
title_full_unstemmed Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission
title_short Therapeutic Potential of Proanthocyanidins in Ulcerative Colitis in Remission
title_sort therapeutic potential of proanthocyanidins in ulcerative colitis in remission
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141196/
https://www.ncbi.nlm.nih.gov/pubmed/32178368
http://dx.doi.org/10.3390/jcm9030771
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