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The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders

The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflamm...

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Autores principales: Missiroli, Sonia, Genovese, Ilaria, Perrone, Mariasole, Vezzani, Bianca, Vitto, Veronica A. M., Giorgi, Carlotta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141240/
https://www.ncbi.nlm.nih.gov/pubmed/32182899
http://dx.doi.org/10.3390/jcm9030740
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author Missiroli, Sonia
Genovese, Ilaria
Perrone, Mariasole
Vezzani, Bianca
Vitto, Veronica A. M.
Giorgi, Carlotta
author_facet Missiroli, Sonia
Genovese, Ilaria
Perrone, Mariasole
Vezzani, Bianca
Vitto, Veronica A. M.
Giorgi, Carlotta
author_sort Missiroli, Sonia
collection PubMed
description The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflammatory signaling, identifying these organelles as a central platform for the control of innate immunity and the inflammatory response. Thus, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Strategies aimed at reestablishing normal mitochondrial physiology could represent both preventive and therapeutic interventions for various pathologies related to exacerbated inflammation. Here, we explore the current understanding of the intricate interplay between mitochondria and the innate immune response in specific inflammatory diseases, such as neurological disorders and cancer.
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spelling pubmed-71412402020-04-10 The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders Missiroli, Sonia Genovese, Ilaria Perrone, Mariasole Vezzani, Bianca Vitto, Veronica A. M. Giorgi, Carlotta J Clin Med Review The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflammatory signaling, identifying these organelles as a central platform for the control of innate immunity and the inflammatory response. Thus, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Strategies aimed at reestablishing normal mitochondrial physiology could represent both preventive and therapeutic interventions for various pathologies related to exacerbated inflammation. Here, we explore the current understanding of the intricate interplay between mitochondria and the innate immune response in specific inflammatory diseases, such as neurological disorders and cancer. MDPI 2020-03-09 /pmc/articles/PMC7141240/ /pubmed/32182899 http://dx.doi.org/10.3390/jcm9030740 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Missiroli, Sonia
Genovese, Ilaria
Perrone, Mariasole
Vezzani, Bianca
Vitto, Veronica A. M.
Giorgi, Carlotta
The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
title The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
title_full The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
title_fullStr The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
title_full_unstemmed The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
title_short The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
title_sort role of mitochondria in inflammation: from cancer to neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141240/
https://www.ncbi.nlm.nih.gov/pubmed/32182899
http://dx.doi.org/10.3390/jcm9030740
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