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Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults

We analyzed inter-individual variability in response to exercise among acutely hospitalized oldest-old adults. In this ancillary analysis of a randomized controlled trial, 268 patients (mean age 88 years) were assigned to a control (n = 125, usual care) or intervention group (n = 143, supervised exe...

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Autores principales: Valenzuela, Pedro L., Ortiz-Alonso, Javier, Bustamante-Ara, Natalia, Vidán, María T., Rodríguez-Romo, Gabriel, Mayordomo-Cava, Jennifer, Javier-González, Marianna, Hidalgo-Gamarra, Mercedes, López-Tatis, Myriel, Valadés-Malagón, Maria Isabel, Santos-Lozano, Alejandro, Serra-Rexach, José Antonio, Lucia, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141266/
https://www.ncbi.nlm.nih.gov/pubmed/32183381
http://dx.doi.org/10.3390/jcm9030797
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author Valenzuela, Pedro L.
Ortiz-Alonso, Javier
Bustamante-Ara, Natalia
Vidán, María T.
Rodríguez-Romo, Gabriel
Mayordomo-Cava, Jennifer
Javier-González, Marianna
Hidalgo-Gamarra, Mercedes
López-Tatis, Myriel
Valadés-Malagón, Maria Isabel
Santos-Lozano, Alejandro
Serra-Rexach, José Antonio
Lucia, Alejandro
author_facet Valenzuela, Pedro L.
Ortiz-Alonso, Javier
Bustamante-Ara, Natalia
Vidán, María T.
Rodríguez-Romo, Gabriel
Mayordomo-Cava, Jennifer
Javier-González, Marianna
Hidalgo-Gamarra, Mercedes
López-Tatis, Myriel
Valadés-Malagón, Maria Isabel
Santos-Lozano, Alejandro
Serra-Rexach, José Antonio
Lucia, Alejandro
author_sort Valenzuela, Pedro L.
collection PubMed
description We analyzed inter-individual variability in response to exercise among acutely hospitalized oldest-old adults. In this ancillary analysis of a randomized controlled trial, 268 patients (mean age 88 years) were assigned to a control (n = 125, usual care) or intervention group (n = 143, supervised exercise, i.e., walking and rising from a chair [1–3 sessions/day]). Intervention group patients were categorized as responders, non-responders, or adverse responders (improved, no change, or impaired function in activities of daily living [ADL, Katz index] from hospital admission to discharge, respectively). We analyzed the association between responsiveness to exercise and variables assessed at baseline (2 weeks pre-admission), admission, during hospitalization, at discharge, and during a subsequent 3-month follow-up. An impaired ADL function and worse nutritional status at admission were associated to a greater responsiveness, whereas a better ADL function at admission, longer hospitalization and lower comorbidity index were associated with a poorer response (p < 0.05). Adverse responders had worse outcomes at discharge and during the follow-up (e.g., impaired physical performance and greater fall number) (p < 0.05). Although exercise intervention helps to prevent ADL function decline in hospitalized oldest-old people, a number of them—particularly those with a better functional/health status at admission and longer hospitalization—are at higher risk of being adverse responders, which can have negative short/middle-term consequences.
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spelling pubmed-71412662020-04-10 Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults Valenzuela, Pedro L. Ortiz-Alonso, Javier Bustamante-Ara, Natalia Vidán, María T. Rodríguez-Romo, Gabriel Mayordomo-Cava, Jennifer Javier-González, Marianna Hidalgo-Gamarra, Mercedes López-Tatis, Myriel Valadés-Malagón, Maria Isabel Santos-Lozano, Alejandro Serra-Rexach, José Antonio Lucia, Alejandro J Clin Med Article We analyzed inter-individual variability in response to exercise among acutely hospitalized oldest-old adults. In this ancillary analysis of a randomized controlled trial, 268 patients (mean age 88 years) were assigned to a control (n = 125, usual care) or intervention group (n = 143, supervised exercise, i.e., walking and rising from a chair [1–3 sessions/day]). Intervention group patients were categorized as responders, non-responders, or adverse responders (improved, no change, or impaired function in activities of daily living [ADL, Katz index] from hospital admission to discharge, respectively). We analyzed the association between responsiveness to exercise and variables assessed at baseline (2 weeks pre-admission), admission, during hospitalization, at discharge, and during a subsequent 3-month follow-up. An impaired ADL function and worse nutritional status at admission were associated to a greater responsiveness, whereas a better ADL function at admission, longer hospitalization and lower comorbidity index were associated with a poorer response (p < 0.05). Adverse responders had worse outcomes at discharge and during the follow-up (e.g., impaired physical performance and greater fall number) (p < 0.05). Although exercise intervention helps to prevent ADL function decline in hospitalized oldest-old people, a number of them—particularly those with a better functional/health status at admission and longer hospitalization—are at higher risk of being adverse responders, which can have negative short/middle-term consequences. MDPI 2020-03-14 /pmc/articles/PMC7141266/ /pubmed/32183381 http://dx.doi.org/10.3390/jcm9030797 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valenzuela, Pedro L.
Ortiz-Alonso, Javier
Bustamante-Ara, Natalia
Vidán, María T.
Rodríguez-Romo, Gabriel
Mayordomo-Cava, Jennifer
Javier-González, Marianna
Hidalgo-Gamarra, Mercedes
López-Tatis, Myriel
Valadés-Malagón, Maria Isabel
Santos-Lozano, Alejandro
Serra-Rexach, José Antonio
Lucia, Alejandro
Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults
title Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults
title_full Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults
title_fullStr Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults
title_full_unstemmed Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults
title_short Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults
title_sort individual responsiveness to physical exercise intervention in acutely hospitalized older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141266/
https://www.ncbi.nlm.nih.gov/pubmed/32183381
http://dx.doi.org/10.3390/jcm9030797
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