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Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial

Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We perform...

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Autores principales: Hulst, Abraham H., Visscher, Maarten J., Cherpanath, Thomas G. V., van de Wouw, Lieke, Godfried, Marc B., Thiel, Bram, Gerritse, Bastiaan M., Scohy, Thierry V., Bouwman, R. Arthur, Willemsen, Mark G. A., Hollmann, Markus W., DeVries, J. Hans, Preckel, Benedikt, Hermanides, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141279/
https://www.ncbi.nlm.nih.gov/pubmed/32131527
http://dx.doi.org/10.3390/jcm9030673
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author Hulst, Abraham H.
Visscher, Maarten J.
Cherpanath, Thomas G. V.
van de Wouw, Lieke
Godfried, Marc B.
Thiel, Bram
Gerritse, Bastiaan M.
Scohy, Thierry V.
Bouwman, R. Arthur
Willemsen, Mark G. A.
Hollmann, Markus W.
DeVries, J. Hans
Preckel, Benedikt
Hermanides, Jeroen
author_facet Hulst, Abraham H.
Visscher, Maarten J.
Cherpanath, Thomas G. V.
van de Wouw, Lieke
Godfried, Marc B.
Thiel, Bram
Gerritse, Bastiaan M.
Scohy, Thierry V.
Bouwman, R. Arthur
Willemsen, Mark G. A.
Hollmann, Markus W.
DeVries, J. Hans
Preckel, Benedikt
Hermanides, Jeroen
author_sort Hulst, Abraham H.
collection PubMed
description Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB , creatinine and lactate were compared between groups. Results: The study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0–30, p = 0.049. Assessment of the right ventricle revealed no difference in function. Conclusions: Patients receiving short-term preoperative liraglutide treatment better maintained normal myocardial function after cardiac surgery. This study warrants further evaluation of the potential beneficial effects of GLP-1 receptor agonists in cardiac surgery patients.
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spelling pubmed-71412792020-04-10 Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial Hulst, Abraham H. Visscher, Maarten J. Cherpanath, Thomas G. V. van de Wouw, Lieke Godfried, Marc B. Thiel, Bram Gerritse, Bastiaan M. Scohy, Thierry V. Bouwman, R. Arthur Willemsen, Mark G. A. Hollmann, Markus W. DeVries, J. Hans Preckel, Benedikt Hermanides, Jeroen J Clin Med Article Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB , creatinine and lactate were compared between groups. Results: The study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0–30, p = 0.049. Assessment of the right ventricle revealed no difference in function. Conclusions: Patients receiving short-term preoperative liraglutide treatment better maintained normal myocardial function after cardiac surgery. This study warrants further evaluation of the potential beneficial effects of GLP-1 receptor agonists in cardiac surgery patients. MDPI 2020-03-02 /pmc/articles/PMC7141279/ /pubmed/32131527 http://dx.doi.org/10.3390/jcm9030673 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hulst, Abraham H.
Visscher, Maarten J.
Cherpanath, Thomas G. V.
van de Wouw, Lieke
Godfried, Marc B.
Thiel, Bram
Gerritse, Bastiaan M.
Scohy, Thierry V.
Bouwman, R. Arthur
Willemsen, Mark G. A.
Hollmann, Markus W.
DeVries, J. Hans
Preckel, Benedikt
Hermanides, Jeroen
Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
title Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
title_full Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
title_fullStr Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
title_full_unstemmed Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
title_short Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
title_sort effects of liraglutide on myocardial function after cardiac surgery: a secondary analysis of the randomised controlled globe trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141279/
https://www.ncbi.nlm.nih.gov/pubmed/32131527
http://dx.doi.org/10.3390/jcm9030673
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