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Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial
Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We perform...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141279/ https://www.ncbi.nlm.nih.gov/pubmed/32131527 http://dx.doi.org/10.3390/jcm9030673 |
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author | Hulst, Abraham H. Visscher, Maarten J. Cherpanath, Thomas G. V. van de Wouw, Lieke Godfried, Marc B. Thiel, Bram Gerritse, Bastiaan M. Scohy, Thierry V. Bouwman, R. Arthur Willemsen, Mark G. A. Hollmann, Markus W. DeVries, J. Hans Preckel, Benedikt Hermanides, Jeroen |
author_facet | Hulst, Abraham H. Visscher, Maarten J. Cherpanath, Thomas G. V. van de Wouw, Lieke Godfried, Marc B. Thiel, Bram Gerritse, Bastiaan M. Scohy, Thierry V. Bouwman, R. Arthur Willemsen, Mark G. A. Hollmann, Markus W. DeVries, J. Hans Preckel, Benedikt Hermanides, Jeroen |
author_sort | Hulst, Abraham H. |
collection | PubMed |
description | Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB , creatinine and lactate were compared between groups. Results: The study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0–30, p = 0.049. Assessment of the right ventricle revealed no difference in function. Conclusions: Patients receiving short-term preoperative liraglutide treatment better maintained normal myocardial function after cardiac surgery. This study warrants further evaluation of the potential beneficial effects of GLP-1 receptor agonists in cardiac surgery patients. |
format | Online Article Text |
id | pubmed-7141279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71412792020-04-10 Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial Hulst, Abraham H. Visscher, Maarten J. Cherpanath, Thomas G. V. van de Wouw, Lieke Godfried, Marc B. Thiel, Bram Gerritse, Bastiaan M. Scohy, Thierry V. Bouwman, R. Arthur Willemsen, Mark G. A. Hollmann, Markus W. DeVries, J. Hans Preckel, Benedikt Hermanides, Jeroen J Clin Med Article Introduction: Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. Methods: We performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB , creatinine and lactate were compared between groups. Results: The study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0–30, p = 0.049. Assessment of the right ventricle revealed no difference in function. Conclusions: Patients receiving short-term preoperative liraglutide treatment better maintained normal myocardial function after cardiac surgery. This study warrants further evaluation of the potential beneficial effects of GLP-1 receptor agonists in cardiac surgery patients. MDPI 2020-03-02 /pmc/articles/PMC7141279/ /pubmed/32131527 http://dx.doi.org/10.3390/jcm9030673 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hulst, Abraham H. Visscher, Maarten J. Cherpanath, Thomas G. V. van de Wouw, Lieke Godfried, Marc B. Thiel, Bram Gerritse, Bastiaan M. Scohy, Thierry V. Bouwman, R. Arthur Willemsen, Mark G. A. Hollmann, Markus W. DeVries, J. Hans Preckel, Benedikt Hermanides, Jeroen Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial |
title | Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial |
title_full | Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial |
title_fullStr | Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial |
title_full_unstemmed | Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial |
title_short | Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial |
title_sort | effects of liraglutide on myocardial function after cardiac surgery: a secondary analysis of the randomised controlled globe trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141279/ https://www.ncbi.nlm.nih.gov/pubmed/32131527 http://dx.doi.org/10.3390/jcm9030673 |
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