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Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers
The main purpose of this pilot investigation was to evaluate the possible relationship among [(99)mTc]Tc-Sestamibi uptake, the presence of breast osteoblast-like cells, and the expression of molecules involved in bone metabolism, such as estrogen receptor, bone morphogenetic proteins-2, and PTX3. To...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141303/ https://www.ncbi.nlm.nih.gov/pubmed/32164267 http://dx.doi.org/10.3390/jcm9030747 |
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author | Urbano, Nicoletta Scimeca, Manuel Di Russo, Carmela Bonanno, Elena Schillaci, Orazio |
author_facet | Urbano, Nicoletta Scimeca, Manuel Di Russo, Carmela Bonanno, Elena Schillaci, Orazio |
author_sort | Urbano, Nicoletta |
collection | PubMed |
description | The main purpose of this pilot investigation was to evaluate the possible relationship among [(99)mTc]Tc-Sestamibi uptake, the presence of breast osteoblast-like cells, and the expression of molecules involved in bone metabolism, such as estrogen receptor, bone morphogenetic proteins-2, and PTX3. To this end, forty consecutive breast cancer patients who underwent both breast-specific gamma imaging with [(99m)Tc]Tc-Sestamibi and breast bioptic procedure were retrospectively enrolled. From each diagnostic paraffin block collected in the study, histological diagnosis, immunohistochemical investigations, and energy dispersive X-ray microanalysis were performed. Our data highlight the possible use of breast-specific gamma imaging with [(99)mTc]Tc-Sestamibi for the early detection of breast cancer lesions expressing bone biomarkers in the presence of breast osteoblast-like cells. Specifically, we show a linear association among sestamibi uptake, the presence of breast osteoblast-like cells, and the expression of estrogen receptor, bone morphogenetics proteins-2, and PTX3. Notably, we also observed an increase of [(99)mTc]Tc-Sestamibi in breast cancer lesions with magnesium-substituted hydroxyapatite. In conclusion, in this pilot study we evaluated data from the nuclear medicine unit and anatomic pathology department on breast cancer osteotropism, identifying a new possible interpretation of Breast Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi analysis. |
format | Online Article Text |
id | pubmed-7141303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71413032020-04-10 Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers Urbano, Nicoletta Scimeca, Manuel Di Russo, Carmela Bonanno, Elena Schillaci, Orazio J Clin Med Article The main purpose of this pilot investigation was to evaluate the possible relationship among [(99)mTc]Tc-Sestamibi uptake, the presence of breast osteoblast-like cells, and the expression of molecules involved in bone metabolism, such as estrogen receptor, bone morphogenetic proteins-2, and PTX3. To this end, forty consecutive breast cancer patients who underwent both breast-specific gamma imaging with [(99m)Tc]Tc-Sestamibi and breast bioptic procedure were retrospectively enrolled. From each diagnostic paraffin block collected in the study, histological diagnosis, immunohistochemical investigations, and energy dispersive X-ray microanalysis were performed. Our data highlight the possible use of breast-specific gamma imaging with [(99)mTc]Tc-Sestamibi for the early detection of breast cancer lesions expressing bone biomarkers in the presence of breast osteoblast-like cells. Specifically, we show a linear association among sestamibi uptake, the presence of breast osteoblast-like cells, and the expression of estrogen receptor, bone morphogenetics proteins-2, and PTX3. Notably, we also observed an increase of [(99)mTc]Tc-Sestamibi in breast cancer lesions with magnesium-substituted hydroxyapatite. In conclusion, in this pilot study we evaluated data from the nuclear medicine unit and anatomic pathology department on breast cancer osteotropism, identifying a new possible interpretation of Breast Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi analysis. MDPI 2020-03-10 /pmc/articles/PMC7141303/ /pubmed/32164267 http://dx.doi.org/10.3390/jcm9030747 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Urbano, Nicoletta Scimeca, Manuel Di Russo, Carmela Bonanno, Elena Schillaci, Orazio Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers |
title | Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers |
title_full | Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers |
title_fullStr | Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers |
title_full_unstemmed | Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers |
title_short | Breast-Specific Gamma Imaging with [(99)mTc]Tc-Sestamibi: An In Vivo Analysis for Early Identification of Breast Cancer Lesions Expressing Bone Biomarkers |
title_sort | breast-specific gamma imaging with [(99)mtc]tc-sestamibi: an in vivo analysis for early identification of breast cancer lesions expressing bone biomarkers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141303/ https://www.ncbi.nlm.nih.gov/pubmed/32164267 http://dx.doi.org/10.3390/jcm9030747 |
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