Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders

Hereditary defects in platelet function are responsible for sometimes severe mucocutaneous hemorrhages. They are a heterogeneous group of abnormalities whose first-line diagnosis typically involves interpreting the results of in vitro light transmission aggregometry (LTA) traces. Interpretation of L...

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Autores principales: Alessi, Marie-Christine, Sié, Pierre, Payrastre, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141357/
https://www.ncbi.nlm.nih.gov/pubmed/32178287
http://dx.doi.org/10.3390/jcm9030763
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author Alessi, Marie-Christine
Sié, Pierre
Payrastre, Bernard
author_facet Alessi, Marie-Christine
Sié, Pierre
Payrastre, Bernard
author_sort Alessi, Marie-Christine
collection PubMed
description Hereditary defects in platelet function are responsible for sometimes severe mucocutaneous hemorrhages. They are a heterogeneous group of abnormalities whose first-line diagnosis typically involves interpreting the results of in vitro light transmission aggregometry (LTA) traces. Interpretation of LTA is challenging. LTA is usually performed in specialized laboratories with expertise in platelet pathophysiology. This review updates knowledge on LTA, describing the various platelet aggregation profiles typical of hereditary platelet disorders to guide the physician in the diagnosis of functional platelet disorders.
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spelling pubmed-71413572020-04-10 Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders Alessi, Marie-Christine Sié, Pierre Payrastre, Bernard J Clin Med Review Hereditary defects in platelet function are responsible for sometimes severe mucocutaneous hemorrhages. They are a heterogeneous group of abnormalities whose first-line diagnosis typically involves interpreting the results of in vitro light transmission aggregometry (LTA) traces. Interpretation of LTA is challenging. LTA is usually performed in specialized laboratories with expertise in platelet pathophysiology. This review updates knowledge on LTA, describing the various platelet aggregation profiles typical of hereditary platelet disorders to guide the physician in the diagnosis of functional platelet disorders. MDPI 2020-03-12 /pmc/articles/PMC7141357/ /pubmed/32178287 http://dx.doi.org/10.3390/jcm9030763 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alessi, Marie-Christine
Sié, Pierre
Payrastre, Bernard
Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
title Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
title_full Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
title_fullStr Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
title_full_unstemmed Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
title_short Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders
title_sort strengths and weaknesses of light transmission aggregometry in diagnosing hereditary platelet function disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141357/
https://www.ncbi.nlm.nih.gov/pubmed/32178287
http://dx.doi.org/10.3390/jcm9030763
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