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Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019
OBJECTIVE: To determine the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory and fecal specimens in children with coronavirus disease 2019 (COVID-19). METHODS: From January 17, 2020 to February 23, 2020, three paediatric cases of COVID-19 were report...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141453/ https://www.ncbi.nlm.nih.gov/pubmed/32276848 http://dx.doi.org/10.1016/j.jmii.2020.03.021 |
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author | Xing, Yu-Han Ni, Wei Wu, Qin Li, Wen-Jie Li, Guo-Ju Wang, Wen-Di Tong, Jian-Ning Song, Xiu-Feng Wing-Kin Wong, Gary Xing, Quan-Sheng |
author_facet | Xing, Yu-Han Ni, Wei Wu, Qin Li, Wen-Jie Li, Guo-Ju Wang, Wen-Di Tong, Jian-Ning Song, Xiu-Feng Wing-Kin Wong, Gary Xing, Quan-Sheng |
author_sort | Xing, Yu-Han |
collection | PubMed |
description | OBJECTIVE: To determine the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory and fecal specimens in children with coronavirus disease 2019 (COVID-19). METHODS: From January 17, 2020 to February 23, 2020, three paediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. Patients were followed up to March 10, 2020, and dynamic profiles of nucleic acid testing results in throat swabs and fecal specimens were closely monitored. RESULTS: Clearance of SARS-CoV-2 in respiratory tract occurred within two weeks after abatement of fever, whereas viral RNA remained detectable in stools of pediatric patients for longer than 4 weeks. Two children had fecal SARS-CoV-2 undetectable 20 days after throat swabs showing negative, while that of another child lagged behind for 8 days. CONCLUSIONS: SARS-CoV-2 may exist in children's gastrointestinal tract for a longer time than respiratory system. Persistent shedding of SARS-CoV-2 in stools of infected children raises the possibility that the virus might be transmitted through contaminated fomites. Massive efforts should be made at all levels to prevent spreading of the infection among children after reopening of kindergartens and schools. |
format | Online Article Text |
id | pubmed-7141453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71414532020-04-09 Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 Xing, Yu-Han Ni, Wei Wu, Qin Li, Wen-Jie Li, Guo-Ju Wang, Wen-Di Tong, Jian-Ning Song, Xiu-Feng Wing-Kin Wong, Gary Xing, Quan-Sheng J Microbiol Immunol Infect Article OBJECTIVE: To determine the dynamic changes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory and fecal specimens in children with coronavirus disease 2019 (COVID-19). METHODS: From January 17, 2020 to February 23, 2020, three paediatric cases of COVID-19 were reported in Qingdao, Shandong Province, China. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. Patients were followed up to March 10, 2020, and dynamic profiles of nucleic acid testing results in throat swabs and fecal specimens were closely monitored. RESULTS: Clearance of SARS-CoV-2 in respiratory tract occurred within two weeks after abatement of fever, whereas viral RNA remained detectable in stools of pediatric patients for longer than 4 weeks. Two children had fecal SARS-CoV-2 undetectable 20 days after throat swabs showing negative, while that of another child lagged behind for 8 days. CONCLUSIONS: SARS-CoV-2 may exist in children's gastrointestinal tract for a longer time than respiratory system. Persistent shedding of SARS-CoV-2 in stools of infected children raises the possibility that the virus might be transmitted through contaminated fomites. Massive efforts should be made at all levels to prevent spreading of the infection among children after reopening of kindergartens and schools. Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. 2020-06 2020-03-28 /pmc/articles/PMC7141453/ /pubmed/32276848 http://dx.doi.org/10.1016/j.jmii.2020.03.021 Text en © 2020 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Xing, Yu-Han Ni, Wei Wu, Qin Li, Wen-Jie Li, Guo-Ju Wang, Wen-Di Tong, Jian-Ning Song, Xiu-Feng Wing-Kin Wong, Gary Xing, Quan-Sheng Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
title | Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
title_full | Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
title_fullStr | Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
title_full_unstemmed | Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
title_short | Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
title_sort | prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141453/ https://www.ncbi.nlm.nih.gov/pubmed/32276848 http://dx.doi.org/10.1016/j.jmii.2020.03.021 |
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