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Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age

In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subject...

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Autores principales: Park, Seung Hun, Cho, Heeyoon, Hwang, Sun Jin, Jeon, Beomseo, Seong, Mincheol, Yeom, Hosuck, Kang, Min Ho, Lim, Han Woong, Shin, Yong Un
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141499/
https://www.ncbi.nlm.nih.gov/pubmed/32213852
http://dx.doi.org/10.3390/jcm9030883
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author Park, Seung Hun
Cho, Heeyoon
Hwang, Sun Jin
Jeon, Beomseo
Seong, Mincheol
Yeom, Hosuck
Kang, Min Ho
Lim, Han Woong
Shin, Yong Un
author_facet Park, Seung Hun
Cho, Heeyoon
Hwang, Sun Jin
Jeon, Beomseo
Seong, Mincheol
Yeom, Hosuck
Kang, Min Ho
Lim, Han Woong
Shin, Yong Un
author_sort Park, Seung Hun
collection PubMed
description In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subjects underwent swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). The vascular density (VD) of the superficial (SCP) and deep capillary plexus (DCP), and choriocapillaris (CCP) were measured using OCTA. The vascular density of each capillary layer, foveal avascular zone (FAZ) area, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), and choroidal thickness (CT) were compared between age groups. Most OCT variables were correlated with OCTA variables. The FAZ area; VD of the SCP, DCP, and CCP; GC-IPL thickness; RT; and CT showed significant difference (p < 0.001) between G1 + G2 and G3 + G4, except for central GC-IPL thickness (p = 0.14) and central RT (p = 0.25). Density of the retinal capillary vasculature reduced and FAZ area increased after age 40, which represents the onset of middle age.
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spelling pubmed-71414992020-04-15 Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age Park, Seung Hun Cho, Heeyoon Hwang, Sun Jin Jeon, Beomseo Seong, Mincheol Yeom, Hosuck Kang, Min Ho Lim, Han Woong Shin, Yong Un J Clin Med Article In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subjects underwent swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). The vascular density (VD) of the superficial (SCP) and deep capillary plexus (DCP), and choriocapillaris (CCP) were measured using OCTA. The vascular density of each capillary layer, foveal avascular zone (FAZ) area, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), and choroidal thickness (CT) were compared between age groups. Most OCT variables were correlated with OCTA variables. The FAZ area; VD of the SCP, DCP, and CCP; GC-IPL thickness; RT; and CT showed significant difference (p < 0.001) between G1 + G2 and G3 + G4, except for central GC-IPL thickness (p = 0.14) and central RT (p = 0.25). Density of the retinal capillary vasculature reduced and FAZ area increased after age 40, which represents the onset of middle age. MDPI 2020-03-24 /pmc/articles/PMC7141499/ /pubmed/32213852 http://dx.doi.org/10.3390/jcm9030883 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Seung Hun
Cho, Heeyoon
Hwang, Sun Jin
Jeon, Beomseo
Seong, Mincheol
Yeom, Hosuck
Kang, Min Ho
Lim, Han Woong
Shin, Yong Un
Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
title Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
title_full Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
title_fullStr Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
title_full_unstemmed Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
title_short Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age
title_sort changes in the retinal microvasculature measured using optical coherence tomography angiography according to age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141499/
https://www.ncbi.nlm.nih.gov/pubmed/32213852
http://dx.doi.org/10.3390/jcm9030883
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