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Novel IL-12 family members shed light on the orchestration of Th1 responses

Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produce...

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Detalles Bibliográficos
Autores principales: Brombacher, Frank, Kastelein, Robert A., Alber, Gottfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141566/
https://www.ncbi.nlm.nih.gov/pubmed/12697453
http://dx.doi.org/10.1016/S1471-4906(03)00067-X
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author Brombacher, Frank
Kastelein, Robert A.
Alber, Gottfried
author_facet Brombacher, Frank
Kastelein, Robert A.
Alber, Gottfried
author_sort Brombacher, Frank
collection PubMed
description Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess. Besides IL-12, other p40-dependent molecules exist that orchestrate Th1 responses. Homodimeric p40 can act as an IL-12 antagonist by competing for its receptor. Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-related protein p19. This heterodimer is known as IL-23 and has activities on memory T cells. Finally, IL-27, the latest addition to this family, is a heterodimer composed of the p40-related protein EBI3 (Epstein–Barr virus-induced gene 3) and the p35-related protein p28. IL-27 is involved in early Th1 initiation.
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spelling pubmed-71415662020-04-09 Novel IL-12 family members shed light on the orchestration of Th1 responses Brombacher, Frank Kastelein, Robert A. Alber, Gottfried Trends Immunol Article Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess. Besides IL-12, other p40-dependent molecules exist that orchestrate Th1 responses. Homodimeric p40 can act as an IL-12 antagonist by competing for its receptor. Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-related protein p19. This heterodimer is known as IL-23 and has activities on memory T cells. Finally, IL-27, the latest addition to this family, is a heterodimer composed of the p40-related protein EBI3 (Epstein–Barr virus-induced gene 3) and the p35-related protein p28. IL-27 is involved in early Th1 initiation. Elsevier Science Ltd. 2003-04 2003-03-29 /pmc/articles/PMC7141566/ /pubmed/12697453 http://dx.doi.org/10.1016/S1471-4906(03)00067-X Text en Copyright © 2003 Elsevier Science Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Brombacher, Frank
Kastelein, Robert A.
Alber, Gottfried
Novel IL-12 family members shed light on the orchestration of Th1 responses
title Novel IL-12 family members shed light on the orchestration of Th1 responses
title_full Novel IL-12 family members shed light on the orchestration of Th1 responses
title_fullStr Novel IL-12 family members shed light on the orchestration of Th1 responses
title_full_unstemmed Novel IL-12 family members shed light on the orchestration of Th1 responses
title_short Novel IL-12 family members shed light on the orchestration of Th1 responses
title_sort novel il-12 family members shed light on the orchestration of th1 responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141566/
https://www.ncbi.nlm.nih.gov/pubmed/12697453
http://dx.doi.org/10.1016/S1471-4906(03)00067-X
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