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Novel IL-12 family members shed light on the orchestration of Th1 responses

Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produce...

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Detalles Bibliográficos
Autores principales: Brombacher, Frank, Kastelein, Robert A., Alber, Gottfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141566/
https://www.ncbi.nlm.nih.gov/pubmed/12697453
http://dx.doi.org/10.1016/S1471-4906(03)00067-X