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Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging
Magnetic resonance electrical properties tomography (MREPT) uses the B1 mapping technique to provide the high-frequency conductivity distribution at Larmor frequency that simultaneously reflects the intracellular and extracellular effects. In biological tissues, the electrical conductivity can be de...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141654/ https://www.ncbi.nlm.nih.gov/pubmed/32267858 http://dx.doi.org/10.1371/journal.pone.0230903 |
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author | Lee, Mun Bae Jahng, Geon-Ho Kim, Hyung Joong Woo, Eung Je Kwon, Oh In |
author_facet | Lee, Mun Bae Jahng, Geon-Ho Kim, Hyung Joong Woo, Eung Je Kwon, Oh In |
author_sort | Lee, Mun Bae |
collection | PubMed |
description | Magnetic resonance electrical properties tomography (MREPT) uses the B1 mapping technique to provide the high-frequency conductivity distribution at Larmor frequency that simultaneously reflects the intracellular and extracellular effects. In biological tissues, the electrical conductivity can be described as the concentration and mobility of charge carriers. For the water molecule diffusivity, diffusion weighted imaging (DWI) measures the random Brownian motion of water molecules within biological tissues. The DWI data can quantitatively access the mobility of microscopic water molecules within biological tissues. By measuring multi-b-value DWI data and the recovered high-frequency conductivity at Larmor frequency, we propose a new method to decompose the conductivity into the total ion concentration and mobility in the extracellular space (ECS) within a routinely applicable MR scan time. Using the measured multi-b-value DWI data, a constrained compartment model is designed to estimate the extracellular volume fraction and extracellular mean diffusivity. With the extracted extracellular volume fraction and water molecule diffusivity, we directly reconstruct the low-frequency electrical properties including the extracellular mean conductivity and extracellular conductivity tensor. To demonstrate the proposed method by comparing the ion concentration and the ion mobility, we conducted human experiments for the proposed low-frequency conductivity imaging. Human experiments verify that the proposed method can recover the low-frequency electrical properties using a conventional MRI scanner. |
format | Online Article Text |
id | pubmed-7141654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-71416542020-04-09 Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging Lee, Mun Bae Jahng, Geon-Ho Kim, Hyung Joong Woo, Eung Je Kwon, Oh In PLoS One Research Article Magnetic resonance electrical properties tomography (MREPT) uses the B1 mapping technique to provide the high-frequency conductivity distribution at Larmor frequency that simultaneously reflects the intracellular and extracellular effects. In biological tissues, the electrical conductivity can be described as the concentration and mobility of charge carriers. For the water molecule diffusivity, diffusion weighted imaging (DWI) measures the random Brownian motion of water molecules within biological tissues. The DWI data can quantitatively access the mobility of microscopic water molecules within biological tissues. By measuring multi-b-value DWI data and the recovered high-frequency conductivity at Larmor frequency, we propose a new method to decompose the conductivity into the total ion concentration and mobility in the extracellular space (ECS) within a routinely applicable MR scan time. Using the measured multi-b-value DWI data, a constrained compartment model is designed to estimate the extracellular volume fraction and extracellular mean diffusivity. With the extracted extracellular volume fraction and water molecule diffusivity, we directly reconstruct the low-frequency electrical properties including the extracellular mean conductivity and extracellular conductivity tensor. To demonstrate the proposed method by comparing the ion concentration and the ion mobility, we conducted human experiments for the proposed low-frequency conductivity imaging. Human experiments verify that the proposed method can recover the low-frequency electrical properties using a conventional MRI scanner. Public Library of Science 2020-04-08 /pmc/articles/PMC7141654/ /pubmed/32267858 http://dx.doi.org/10.1371/journal.pone.0230903 Text en © 2020 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Mun Bae Jahng, Geon-Ho Kim, Hyung Joong Woo, Eung Je Kwon, Oh In Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging |
title | Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging |
title_full | Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging |
title_fullStr | Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging |
title_full_unstemmed | Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging |
title_short | Extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at Larmor-frequency using multi-b-value diffusion-weighted imaging |
title_sort | extracellular electrical conductivity property imaging by decomposition of high-frequency conductivity at larmor-frequency using multi-b-value diffusion-weighted imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141654/ https://www.ncbi.nlm.nih.gov/pubmed/32267858 http://dx.doi.org/10.1371/journal.pone.0230903 |
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