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TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models

Genetic redundancy can be exploited to identify therapeutic targets for inherited disorders. We explored this possibility in DYT1 dystonia, a neurodevelopmental movement disorder caused by a loss-of-function (LOF) mutation in the TOR1A gene encoding torsinA. Prior work demonstrates that torsinA and...

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Detalles Bibliográficos
Autores principales:	Li, Jay, Liang, Chun-Chi, Pappas, Samuel S, Dauer, William T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141835/ https://www.ncbi.nlm.nih.gov/pubmed/32202496 http://dx.doi.org/10.7554/eLife.54285

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