Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer

Eukaryotic translation initiation factor 4E (eIF4E) selectively promotes translation of mRNAs with atypically long and structured 5′-UTRs and has been implicated in drug resistance. Through genome-wide transcriptome and translatome analysis we revealed eIF4E overexpression could promote cellular act...

Descripción completa

Detalles Bibliográficos
Autores principales: Gong, Chun, Tsoi, Ho, Mok, Ka Chun, Cheung, Jenny, Man, Ellen P. S., Fujino, Kazunari, Wong, Ashely, Lam, Eric W. F., Khoo, Ui-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142019/
https://www.ncbi.nlm.nih.gov/pubmed/32066877
http://dx.doi.org/10.1038/s41388-020-1210-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142019/
https://www.ncbi.nlm.nih.gov/pubmed/32066877
http://dx.doi.org/10.1038/s41388-020-1210-y

Ejemplares similares