NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis

NOTCH receptor signaling plays a pivotal role in liver homeostasis and hepatocarcinogenesis. However, the role of NOTCH pathway mutations and the NOTCH target gene HES5 in liver tumorigenesis are poorly understood. Here we performed whole-exome sequencing of 54 human HCC specimens and compared the p...

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Detalles Bibliográficos
Autores principales: Luiken, Sarah, Fraas, Angelika, Bieg, Matthias, Sugiyanto, Raisatun, Goeppert, Benjamin, Singer, Stephan, Ploeger, Carolin, Warsow, Gregor, Marquardt, Jens U., Sticht, Carsten, De La Torre, Carolina, Pusch, Stefan, Mehrabi, Arianeb, Gretz, Norbert, Schlesner, Matthias, Eils, Roland, Schirmacher, Peter, Longerich, Thomas, Roessler, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142020/
https://www.ncbi.nlm.nih.gov/pubmed/32055024
http://dx.doi.org/10.1038/s41388-020-1198-3

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