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Downregulation of SFRP1 is a protumorigenic event in hepatoblastoma and correlates with beta-catenin mutations

BACKGROUND: Hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC) are the most common malignant liver tumors in childhood. Both tumor types exhibit genetic and epigenetic alterations in the WNT/β-catenin signaling pathway, which is a key regulator of liver progenitor cells in embryonic de...

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Detalles Bibliográficos
Autores principales:	Regel, Ivonne, Eichenmüller, Melanie, Mahajan, Ujjwal Mukund, Hagl, Beate, Benitz, Simone, Häberle, Beate, Vokuhl, Christian, von Schweinitz, Dietrich, Kappler, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article – Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142044/ https://www.ncbi.nlm.nih.gov/pubmed/32189106 http://dx.doi.org/10.1007/s00432-020-03182-1

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