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Sex specific cognitive differences in Parkinson disease

Parkinson disease (PD) is a progressive neurodegenerative disorder that is 1.5 times more common in males than in females. While motor progression tends to be more aggressive in males, little is known about sex difference in cognitive progression. We tested the hypothesis that there are sex differen...

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Autores principales: Reekes, Tyler Harrison, Higginson, Christopher Ian, Ledbetter, Christina Raye, Sathivadivel, Niroshan, Zweig, Richard Matthew, Disbrow, Elizabeth Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142103/
https://www.ncbi.nlm.nih.gov/pubmed/32284961
http://dx.doi.org/10.1038/s41531-020-0109-1
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author Reekes, Tyler Harrison
Higginson, Christopher Ian
Ledbetter, Christina Raye
Sathivadivel, Niroshan
Zweig, Richard Matthew
Disbrow, Elizabeth Ann
author_facet Reekes, Tyler Harrison
Higginson, Christopher Ian
Ledbetter, Christina Raye
Sathivadivel, Niroshan
Zweig, Richard Matthew
Disbrow, Elizabeth Ann
author_sort Reekes, Tyler Harrison
collection PubMed
description Parkinson disease (PD) is a progressive neurodegenerative disorder that is 1.5 times more common in males than in females. While motor progression tends to be more aggressive in males, little is known about sex difference in cognitive progression. We tested the hypothesis that there are sex differences in cognitive dysfunction in non-demented PD. We evaluated 84 participants (38 females) with PD and 59 controls (27 females) for demographic variables and cognitive function, including attention, working memory, executive function, and processing speed. Multivariate ANOVA revealed no significant differences between groups for demographic variables, including age, years of education, global cogntition, daytime sleepiness, predicted premorbid IQ, UPDRS score, PD phenotype, or disease duration. For cognitive variables, we found poorer performance in males versus females with PD for measures of executive function and processing speed, but no difference between male and female controls. Specifically, PD males showed greater deficits in Verbal Fluency (category fluency, category switching, and category switching accuracy), Color Word Interference (inhibition), and speed of processing (SDMT). There were no differences in measures of working memory or attention across sex and inconsistent findings for switching. Our data indicate that males with PD have significantly greater executive and processing speed impairments compared to females despite no differences in demographic variables or other measures of disease severity. Our findings are consistent with the steeper slope of disease progression reported in males with PD.
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spelling pubmed-71421032020-04-13 Sex specific cognitive differences in Parkinson disease Reekes, Tyler Harrison Higginson, Christopher Ian Ledbetter, Christina Raye Sathivadivel, Niroshan Zweig, Richard Matthew Disbrow, Elizabeth Ann NPJ Parkinsons Dis Article Parkinson disease (PD) is a progressive neurodegenerative disorder that is 1.5 times more common in males than in females. While motor progression tends to be more aggressive in males, little is known about sex difference in cognitive progression. We tested the hypothesis that there are sex differences in cognitive dysfunction in non-demented PD. We evaluated 84 participants (38 females) with PD and 59 controls (27 females) for demographic variables and cognitive function, including attention, working memory, executive function, and processing speed. Multivariate ANOVA revealed no significant differences between groups for demographic variables, including age, years of education, global cogntition, daytime sleepiness, predicted premorbid IQ, UPDRS score, PD phenotype, or disease duration. For cognitive variables, we found poorer performance in males versus females with PD for measures of executive function and processing speed, but no difference between male and female controls. Specifically, PD males showed greater deficits in Verbal Fluency (category fluency, category switching, and category switching accuracy), Color Word Interference (inhibition), and speed of processing (SDMT). There were no differences in measures of working memory or attention across sex and inconsistent findings for switching. Our data indicate that males with PD have significantly greater executive and processing speed impairments compared to females despite no differences in demographic variables or other measures of disease severity. Our findings are consistent with the steeper slope of disease progression reported in males with PD. Nature Publishing Group UK 2020-04-08 /pmc/articles/PMC7142103/ /pubmed/32284961 http://dx.doi.org/10.1038/s41531-020-0109-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Reekes, Tyler Harrison
Higginson, Christopher Ian
Ledbetter, Christina Raye
Sathivadivel, Niroshan
Zweig, Richard Matthew
Disbrow, Elizabeth Ann
Sex specific cognitive differences in Parkinson disease
title Sex specific cognitive differences in Parkinson disease
title_full Sex specific cognitive differences in Parkinson disease
title_fullStr Sex specific cognitive differences in Parkinson disease
title_full_unstemmed Sex specific cognitive differences in Parkinson disease
title_short Sex specific cognitive differences in Parkinson disease
title_sort sex specific cognitive differences in parkinson disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142103/
https://www.ncbi.nlm.nih.gov/pubmed/32284961
http://dx.doi.org/10.1038/s41531-020-0109-1
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