Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro

Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extract...

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Detalles Bibliográficos
Autores principales: Sun, Zhenyu, Zeng, Junkai, Wang, Wenjuan, Jia, Xinlin, Wu, Qiang, Yu, Degang, Mao, Yuanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142243/
https://www.ncbi.nlm.nih.gov/pubmed/32300300
http://dx.doi.org/10.3389/fphar.2020.00389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142243/
https://www.ncbi.nlm.nih.gov/pubmed/32300300
http://dx.doi.org/10.3389/fphar.2020.00389

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