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Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating cancer cell growth, proliferation, cell cycle progression, apoptosis, senescence, angiogenesis, and immune response. Recent studies...

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Detalles Bibliográficos
Autores principales:	Qi, Si-Min, Cheng, Gang, Cheng, Xiang-Dong, Xu, Zhiyuan, Xu, Beihua, Zhang, Wei-Dong, Qin, Jiang-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142254/ https://www.ncbi.nlm.nih.gov/pubmed/32300595 http://dx.doi.org/10.3389/fcell.2020.00233

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