Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

The APOBEC3 (APOBEC3A‐H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single‐stranded (ss) DNA by deamination of cytosines to produce uracil residues. However, APOBEC3‐mediated mutagenesis of viral and cancer DNA promotes its evolution, th...

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Detalles Bibliográficos
Autores principales: Kvach, Maksim V., Barzak, Fareeda M., Harjes, Stefan, Schares, Henry A. M., Kurup, Harikrishnan M., Jones, Katherine F., Sutton, Lorraine, Donahue, John, D'Aquila, Richard T., Jameson, Geoffrey B., Harki, Daniel A., Krause, Kurt L., Harjes, Elena, Filichev, Vyacheslav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142307/
https://www.ncbi.nlm.nih.gov/pubmed/31633265
http://dx.doi.org/10.1002/cbic.201900505

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