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Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014

Background and objectives: Goodpasture’s syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture’s syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among p...

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Autores principales: Thongprayoon, Charat, Kaewput, Wisit, Boonpheng, Boonphiphop, Ungprasert, Patompong, Bathini, Tarun, Srivali, Narat, Vallabhajosyula, Saraschandra, Castaneda, Jorge L., Monga, Divya, Kanduri, Swetha R., Medaura, Juan, Cheungpasitporn, Wisit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142422/
https://www.ncbi.nlm.nih.gov/pubmed/32121573
http://dx.doi.org/10.3390/medicina56030103
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author Thongprayoon, Charat
Kaewput, Wisit
Boonpheng, Boonphiphop
Ungprasert, Patompong
Bathini, Tarun
Srivali, Narat
Vallabhajosyula, Saraschandra
Castaneda, Jorge L.
Monga, Divya
Kanduri, Swetha R.
Medaura, Juan
Cheungpasitporn, Wisit
author_facet Thongprayoon, Charat
Kaewput, Wisit
Boonpheng, Boonphiphop
Ungprasert, Patompong
Bathini, Tarun
Srivali, Narat
Vallabhajosyula, Saraschandra
Castaneda, Jorge L.
Monga, Divya
Kanduri, Swetha R.
Medaura, Juan
Cheungpasitporn, Wisit
author_sort Thongprayoon, Charat
collection PubMed
description Background and objectives: Goodpasture’s syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture’s syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone.
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spelling pubmed-71424222020-04-15 Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014 Thongprayoon, Charat Kaewput, Wisit Boonpheng, Boonphiphop Ungprasert, Patompong Bathini, Tarun Srivali, Narat Vallabhajosyula, Saraschandra Castaneda, Jorge L. Monga, Divya Kanduri, Swetha R. Medaura, Juan Cheungpasitporn, Wisit Medicina (Kaunas) Article Background and objectives: Goodpasture’s syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture’s syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone. MDPI 2020-03-01 /pmc/articles/PMC7142422/ /pubmed/32121573 http://dx.doi.org/10.3390/medicina56030103 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thongprayoon, Charat
Kaewput, Wisit
Boonpheng, Boonphiphop
Ungprasert, Patompong
Bathini, Tarun
Srivali, Narat
Vallabhajosyula, Saraschandra
Castaneda, Jorge L.
Monga, Divya
Kanduri, Swetha R.
Medaura, Juan
Cheungpasitporn, Wisit
Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014
title Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014
title_full Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014
title_fullStr Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014
title_full_unstemmed Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014
title_short Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014
title_sort impact of anca-associated vasculitis on outcomes of hospitalizations for goodpasture’s syndrome in the united states: nationwide inpatient sample 2003–2014
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142422/
https://www.ncbi.nlm.nih.gov/pubmed/32121573
http://dx.doi.org/10.3390/medicina56030103
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