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Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties

Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention of...

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Autores principales: Luitel, Himal, Novoyatleva, Tatyana, Sydykov, Akylbek, Petrovic, Aleksandar, Mamazhakypov, Argen, Devkota, Bhuminand, Wygrecka, Malgorzata, Ghofrani, Hossein Ardeschir, Avdeev, Sergey, Schermuly, Ralph Theo, Kosanovic, Djuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142425/
https://www.ncbi.nlm.nih.gov/pubmed/32188043
http://dx.doi.org/10.3390/medicina56030131
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author Luitel, Himal
Novoyatleva, Tatyana
Sydykov, Akylbek
Petrovic, Aleksandar
Mamazhakypov, Argen
Devkota, Bhuminand
Wygrecka, Malgorzata
Ghofrani, Hossein Ardeschir
Avdeev, Sergey
Schermuly, Ralph Theo
Kosanovic, Djuro
author_facet Luitel, Himal
Novoyatleva, Tatyana
Sydykov, Akylbek
Petrovic, Aleksandar
Mamazhakypov, Argen
Devkota, Bhuminand
Wygrecka, Malgorzata
Ghofrani, Hossein Ardeschir
Avdeev, Sergey
Schermuly, Ralph Theo
Kosanovic, Djuro
author_sort Luitel, Himal
collection PubMed
description Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention of the general public and scientific communities. The entomogenous fungus Yarsagumba (Cordyceps sinensis) and its biologically active ingredient cordycepin may represent the therapeutic option for this incurable disease, owing to their anti-inflammatory, vasodilatory and anti-oxidative effects. Methods: In this study, we investigated whether Yarsagumba extract and cordycepin possess anti-proliferative and vasorelaxant properties in the context of PH, using 5-bromo-2’-deoxyuridine assay and isolated mice lungs, respectively. Results: Our results revealed that Yarsagumba extract and its bioactive compound cordycepin significantly attenuated the proliferation of human pulmonary artery smooth muscle cells derived from donor and PH subjects. In isolated murine lungs, only Yarsagumba extract, but not cordycepin, resulted in vasodilatation, indicating the probable existence of other bioactive metabolites present in Yarsagumba that may be responsible for this outcome. Conclusion: Future comprehensive in vivo and in vitro research is crucially needed to discover the profound mechanistic insights with regard to this promising therapeutic potency of Yarsagumba extract and to provide further evidence as to whether it can be used as a strategy for the treatment of PH.
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spelling pubmed-71424252020-04-15 Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties Luitel, Himal Novoyatleva, Tatyana Sydykov, Akylbek Petrovic, Aleksandar Mamazhakypov, Argen Devkota, Bhuminand Wygrecka, Malgorzata Ghofrani, Hossein Ardeschir Avdeev, Sergey Schermuly, Ralph Theo Kosanovic, Djuro Medicina (Kaunas) Article Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention of the general public and scientific communities. The entomogenous fungus Yarsagumba (Cordyceps sinensis) and its biologically active ingredient cordycepin may represent the therapeutic option for this incurable disease, owing to their anti-inflammatory, vasodilatory and anti-oxidative effects. Methods: In this study, we investigated whether Yarsagumba extract and cordycepin possess anti-proliferative and vasorelaxant properties in the context of PH, using 5-bromo-2’-deoxyuridine assay and isolated mice lungs, respectively. Results: Our results revealed that Yarsagumba extract and its bioactive compound cordycepin significantly attenuated the proliferation of human pulmonary artery smooth muscle cells derived from donor and PH subjects. In isolated murine lungs, only Yarsagumba extract, but not cordycepin, resulted in vasodilatation, indicating the probable existence of other bioactive metabolites present in Yarsagumba that may be responsible for this outcome. Conclusion: Future comprehensive in vivo and in vitro research is crucially needed to discover the profound mechanistic insights with regard to this promising therapeutic potency of Yarsagumba extract and to provide further evidence as to whether it can be used as a strategy for the treatment of PH. MDPI 2020-03-16 /pmc/articles/PMC7142425/ /pubmed/32188043 http://dx.doi.org/10.3390/medicina56030131 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luitel, Himal
Novoyatleva, Tatyana
Sydykov, Akylbek
Petrovic, Aleksandar
Mamazhakypov, Argen
Devkota, Bhuminand
Wygrecka, Malgorzata
Ghofrani, Hossein Ardeschir
Avdeev, Sergey
Schermuly, Ralph Theo
Kosanovic, Djuro
Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
title Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
title_full Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
title_fullStr Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
title_full_unstemmed Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
title_short Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
title_sort yarsagumba is a promising therapeutic option for treatment of pulmonary hypertension due to the potent anti-proliferative and vasorelaxant properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142425/
https://www.ncbi.nlm.nih.gov/pubmed/32188043
http://dx.doi.org/10.3390/medicina56030131
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