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Gut Microbial-Derived Metabolomics of Asthma

In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbio...

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Autores principales: Lee-Sarwar, Kathleen A., Lasky-Su, Jessica, Kelly, Rachel S., Litonjua, Augusto A., Weiss, Scott T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142494/
https://www.ncbi.nlm.nih.gov/pubmed/32155960
http://dx.doi.org/10.3390/metabo10030097
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author Lee-Sarwar, Kathleen A.
Lasky-Su, Jessica
Kelly, Rachel S.
Litonjua, Augusto A.
Weiss, Scott T.
author_facet Lee-Sarwar, Kathleen A.
Lasky-Su, Jessica
Kelly, Rachel S.
Litonjua, Augusto A.
Weiss, Scott T.
author_sort Lee-Sarwar, Kathleen A.
collection PubMed
description In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbiome and metabolomic pathways involved in immune system ontogeny. Metabolite classes with existing evidence that microbial-derived products influence asthma risk include short chain fatty acids, polyunsaturated fatty acids and bile acids. While tryptophan metabolites and sphingolipids have known associations with asthma, additional research is needed to clarify the extent to which the microbiome contributes to the effects of these metabolites on asthma. These metabolite classes can influence immune function in one of two ways: (i) promoting growth or maturity of certain immune cell populations or (ii) influencing antigenic load by enhancing the number or species of specific bacteria. A more comprehensive understanding of how gut microbes and metabolites interact to modify asthma risk and morbidity will pave the way for targeted diagnostics and treatments.
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spelling pubmed-71424942020-04-15 Gut Microbial-Derived Metabolomics of Asthma Lee-Sarwar, Kathleen A. Lasky-Su, Jessica Kelly, Rachel S. Litonjua, Augusto A. Weiss, Scott T. Metabolites Review In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbiome and metabolomic pathways involved in immune system ontogeny. Metabolite classes with existing evidence that microbial-derived products influence asthma risk include short chain fatty acids, polyunsaturated fatty acids and bile acids. While tryptophan metabolites and sphingolipids have known associations with asthma, additional research is needed to clarify the extent to which the microbiome contributes to the effects of these metabolites on asthma. These metabolite classes can influence immune function in one of two ways: (i) promoting growth or maturity of certain immune cell populations or (ii) influencing antigenic load by enhancing the number or species of specific bacteria. A more comprehensive understanding of how gut microbes and metabolites interact to modify asthma risk and morbidity will pave the way for targeted diagnostics and treatments. MDPI 2020-03-06 /pmc/articles/PMC7142494/ /pubmed/32155960 http://dx.doi.org/10.3390/metabo10030097 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee-Sarwar, Kathleen A.
Lasky-Su, Jessica
Kelly, Rachel S.
Litonjua, Augusto A.
Weiss, Scott T.
Gut Microbial-Derived Metabolomics of Asthma
title Gut Microbial-Derived Metabolomics of Asthma
title_full Gut Microbial-Derived Metabolomics of Asthma
title_fullStr Gut Microbial-Derived Metabolomics of Asthma
title_full_unstemmed Gut Microbial-Derived Metabolomics of Asthma
title_short Gut Microbial-Derived Metabolomics of Asthma
title_sort gut microbial-derived metabolomics of asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142494/
https://www.ncbi.nlm.nih.gov/pubmed/32155960
http://dx.doi.org/10.3390/metabo10030097
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