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Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?

Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attem...

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Autores principales: Liatsos, Christos, Papaefthymiou, Apostolis, Kyriakos, Nikolaos, Giakoumis, Marios, Kountouras, Jannis, Galanopoulos, Michail, Apostolopoulos, Periklis, Georgopoulos, Sotirios D., Mavrogiannis, Christos, Exadaktylos, Aristomenis K., Srivastava, David Shiva, Rokkas, Theodore, Doulberis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142601/
https://www.ncbi.nlm.nih.gov/pubmed/32197498
http://dx.doi.org/10.3390/medicina56030133
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author Liatsos, Christos
Papaefthymiou, Apostolis
Kyriakos, Nikolaos
Giakoumis, Marios
Kountouras, Jannis
Galanopoulos, Michail
Apostolopoulos, Periklis
Georgopoulos, Sotirios D.
Mavrogiannis, Christos
Exadaktylos, Aristomenis K.
Srivastava, David Shiva
Rokkas, Theodore
Doulberis, Michael
author_facet Liatsos, Christos
Papaefthymiou, Apostolis
Kyriakos, Nikolaos
Giakoumis, Marios
Kountouras, Jannis
Galanopoulos, Michail
Apostolopoulos, Periklis
Georgopoulos, Sotirios D.
Mavrogiannis, Christos
Exadaktylos, Aristomenis K.
Srivastava, David Shiva
Rokkas, Theodore
Doulberis, Michael
author_sort Liatsos, Christos
collection PubMed
description Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attempt “outpatient” Hp eradication treatment were estimated as the following: (I) first-line regimens: 10 and 14 days standard triple, 10 and 14 days sequential, 10 and 14 days concomitant non-bismuth quadruple, 14 days hybrid, (II) second-line salvage regimens: 10 and 14 days levofloxacin-containing triple regimens. Treatment costs using prototypes and/or generic drugs were calculated. Drug prices were collected and confirmed from two official online medical databases including all medicines approved by the Greek National Organization for Medicines. Regimens based on generics were more affordable than prototypes and those including pantoprazole yielded the lowest prices (mean: 27.84 €). Paradoxically, 10-day concomitant and 14-day hybrid regimens (currently providing good (90–94%) first-line eradication rates in Greece) cost the same (mean: 34.76 €). The expenditures for Hp eradication treatment regimens were estimated thoroughly for the first time in Greece. These data should be taken into account by Public Health policymakers both in Greece and the European Union, aiming for a better and less expensive therapeutic approach.
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spelling pubmed-71426012020-04-15 Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care? Liatsos, Christos Papaefthymiou, Apostolis Kyriakos, Nikolaos Giakoumis, Marios Kountouras, Jannis Galanopoulos, Michail Apostolopoulos, Periklis Georgopoulos, Sotirios D. Mavrogiannis, Christos Exadaktylos, Aristomenis K. Srivastava, David Shiva Rokkas, Theodore Doulberis, Michael Medicina (Kaunas) Article Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attempt “outpatient” Hp eradication treatment were estimated as the following: (I) first-line regimens: 10 and 14 days standard triple, 10 and 14 days sequential, 10 and 14 days concomitant non-bismuth quadruple, 14 days hybrid, (II) second-line salvage regimens: 10 and 14 days levofloxacin-containing triple regimens. Treatment costs using prototypes and/or generic drugs were calculated. Drug prices were collected and confirmed from two official online medical databases including all medicines approved by the Greek National Organization for Medicines. Regimens based on generics were more affordable than prototypes and those including pantoprazole yielded the lowest prices (mean: 27.84 €). Paradoxically, 10-day concomitant and 14-day hybrid regimens (currently providing good (90–94%) first-line eradication rates in Greece) cost the same (mean: 34.76 €). The expenditures for Hp eradication treatment regimens were estimated thoroughly for the first time in Greece. These data should be taken into account by Public Health policymakers both in Greece and the European Union, aiming for a better and less expensive therapeutic approach. MDPI 2020-03-18 /pmc/articles/PMC7142601/ /pubmed/32197498 http://dx.doi.org/10.3390/medicina56030133 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liatsos, Christos
Papaefthymiou, Apostolis
Kyriakos, Nikolaos
Giakoumis, Marios
Kountouras, Jannis
Galanopoulos, Michail
Apostolopoulos, Periklis
Georgopoulos, Sotirios D.
Mavrogiannis, Christos
Exadaktylos, Aristomenis K.
Srivastava, David Shiva
Rokkas, Theodore
Doulberis, Michael
Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
title Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
title_full Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
title_fullStr Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
title_full_unstemmed Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
title_short Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?
title_sort evaluation of the direct economic cost per eradication treatment regimen against helicobacter pylori infection in greece: do national health policy-makers need to care?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142601/
https://www.ncbi.nlm.nih.gov/pubmed/32197498
http://dx.doi.org/10.3390/medicina56030133
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