Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies (‘precision vaccination’). If baseline immune signatures ar...

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Autores principales: Tsang, John S., Dobaño, Carlota, VanDamme, Pierre, Moncunill, Gemma, Marchant, Arnaud, Othman, Rym Ben, Sadarangani, Manish, Koff, Wayne C., Kollmann, Tobias R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142696/
https://www.ncbi.nlm.nih.gov/pubmed/32340868
http://dx.doi.org/10.1016/j.it.2020.04.001
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author Tsang, John S.
Dobaño, Carlota
VanDamme, Pierre
Moncunill, Gemma
Marchant, Arnaud
Othman, Rym Ben
Sadarangani, Manish
Koff, Wayne C.
Kollmann, Tobias R.
author_facet Tsang, John S.
Dobaño, Carlota
VanDamme, Pierre
Moncunill, Gemma
Marchant, Arnaud
Othman, Rym Ben
Sadarangani, Manish
Koff, Wayne C.
Kollmann, Tobias R.
author_sort Tsang, John S.
collection PubMed
description Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies (‘precision vaccination’). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health.
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spelling pubmed-71426962020-04-09 Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome? Tsang, John S. Dobaño, Carlota VanDamme, Pierre Moncunill, Gemma Marchant, Arnaud Othman, Rym Ben Sadarangani, Manish Koff, Wayne C. Kollmann, Tobias R. Trends Immunol Article Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies (‘precision vaccination’). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health. The Authors. Published by Elsevier Ltd. 2020-06 2020-04-08 /pmc/articles/PMC7142696/ /pubmed/32340868 http://dx.doi.org/10.1016/j.it.2020.04.001 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tsang, John S.
Dobaño, Carlota
VanDamme, Pierre
Moncunill, Gemma
Marchant, Arnaud
Othman, Rym Ben
Sadarangani, Manish
Koff, Wayne C.
Kollmann, Tobias R.
Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
title Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
title_full Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
title_fullStr Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
title_full_unstemmed Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
title_short Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
title_sort improving vaccine-induced immunity: can baseline predict outcome?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142696/
https://www.ncbi.nlm.nih.gov/pubmed/32340868
http://dx.doi.org/10.1016/j.it.2020.04.001
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