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Advances in Research on the Bioactivity of Alginate Oligosaccharides

Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS i...

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Detalles Bibliográficos
Autores principales: Xing, Maochen, Cao, Qi, Wang, Yu, Xiao, Han, Zhao, Jiarui, Zhang, Qing, Ji, Aiguo, Song, Shuliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142810/
https://www.ncbi.nlm.nih.gov/pubmed/32121067
http://dx.doi.org/10.3390/md18030144
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author Xing, Maochen
Cao, Qi
Wang, Yu
Xiao, Han
Zhao, Jiarui
Zhang, Qing
Ji, Aiguo
Song, Shuliang
author_facet Xing, Maochen
Cao, Qi
Wang, Yu
Xiao, Han
Zhao, Jiarui
Zhang, Qing
Ji, Aiguo
Song, Shuliang
author_sort Xing, Maochen
collection PubMed
description Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS is closely related to the diversity of their structures. AOS with a specific structure and distinct applications can be obtained by different methods of alginate degradation. This review focuses on recent advances in the biological activity of alginate and its derivatives, including their anti-tumor, anti-oxidative, immunoregulatory, anti-inflammatory, neuroprotective, antibacterial, hypolipidemic, antihypertensive, and hypoglycemic properties, as well as the ability to suppress obesity and promote cell proliferation and regulate plant growth. We hope that this review will provide theoretical basis and inspiration for the high-value research developments and utilization of AOS-related products.
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spelling pubmed-71428102020-04-14 Advances in Research on the Bioactivity of Alginate Oligosaccharides Xing, Maochen Cao, Qi Wang, Yu Xiao, Han Zhao, Jiarui Zhang, Qing Ji, Aiguo Song, Shuliang Mar Drugs Review Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS is closely related to the diversity of their structures. AOS with a specific structure and distinct applications can be obtained by different methods of alginate degradation. This review focuses on recent advances in the biological activity of alginate and its derivatives, including their anti-tumor, anti-oxidative, immunoregulatory, anti-inflammatory, neuroprotective, antibacterial, hypolipidemic, antihypertensive, and hypoglycemic properties, as well as the ability to suppress obesity and promote cell proliferation and regulate plant growth. We hope that this review will provide theoretical basis and inspiration for the high-value research developments and utilization of AOS-related products. MDPI 2020-02-28 /pmc/articles/PMC7142810/ /pubmed/32121067 http://dx.doi.org/10.3390/md18030144 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xing, Maochen
Cao, Qi
Wang, Yu
Xiao, Han
Zhao, Jiarui
Zhang, Qing
Ji, Aiguo
Song, Shuliang
Advances in Research on the Bioactivity of Alginate Oligosaccharides
title Advances in Research on the Bioactivity of Alginate Oligosaccharides
title_full Advances in Research on the Bioactivity of Alginate Oligosaccharides
title_fullStr Advances in Research on the Bioactivity of Alginate Oligosaccharides
title_full_unstemmed Advances in Research on the Bioactivity of Alginate Oligosaccharides
title_short Advances in Research on the Bioactivity of Alginate Oligosaccharides
title_sort advances in research on the bioactivity of alginate oligosaccharides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142810/
https://www.ncbi.nlm.nih.gov/pubmed/32121067
http://dx.doi.org/10.3390/md18030144
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