Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer

Defect-engineered photonic crystal (PC) microcavities were fabricated by UV photolithography and their corresponding sensitivities to biomarkers in patient plasma samples were compared for different resonant microcavity characteristics of quality factor Q and biomarker fill fraction. Three different...

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Autores principales: Yang, Chun-Ju, Yan, Hai, Tang, Naimei, Zou, Yi, Al-Hadeethi, Yas, Xu, Xiaochuan, Dalir, Hamed, Chen, Ray T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142818/
https://www.ncbi.nlm.nih.gov/pubmed/32182956
http://dx.doi.org/10.3390/mi11030282
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author Yang, Chun-Ju
Yan, Hai
Tang, Naimei
Zou, Yi
Al-Hadeethi, Yas
Xu, Xiaochuan
Dalir, Hamed
Chen, Ray T.
author_facet Yang, Chun-Ju
Yan, Hai
Tang, Naimei
Zou, Yi
Al-Hadeethi, Yas
Xu, Xiaochuan
Dalir, Hamed
Chen, Ray T.
author_sort Yang, Chun-Ju
collection PubMed
description Defect-engineered photonic crystal (PC) microcavities were fabricated by UV photolithography and their corresponding sensitivities to biomarkers in patient plasma samples were compared for different resonant microcavity characteristics of quality factor Q and biomarker fill fraction. Three different biomarkers in plasma from pancreatic cancer patients were experimentally detected by conventional L13 defect-engineered microcavities without nanoholes and higher sensitivity L13 PC microcavities with nanoholes. 8.8 femto-molar (0.334 pg/mL) concentration of pancreatic cancer biomarker in patient plasma samples was experimentally detected which are 50 times dilution than ELISA in a PC microcavity with high quality factor and high analyte fill fraction.
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spelling pubmed-71428182020-04-14 Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer Yang, Chun-Ju Yan, Hai Tang, Naimei Zou, Yi Al-Hadeethi, Yas Xu, Xiaochuan Dalir, Hamed Chen, Ray T. Micromachines (Basel) Article Defect-engineered photonic crystal (PC) microcavities were fabricated by UV photolithography and their corresponding sensitivities to biomarkers in patient plasma samples were compared for different resonant microcavity characteristics of quality factor Q and biomarker fill fraction. Three different biomarkers in plasma from pancreatic cancer patients were experimentally detected by conventional L13 defect-engineered microcavities without nanoholes and higher sensitivity L13 PC microcavities with nanoholes. 8.8 femto-molar (0.334 pg/mL) concentration of pancreatic cancer biomarker in patient plasma samples was experimentally detected which are 50 times dilution than ELISA in a PC microcavity with high quality factor and high analyte fill fraction. MDPI 2020-03-09 /pmc/articles/PMC7142818/ /pubmed/32182956 http://dx.doi.org/10.3390/mi11030282 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Chun-Ju
Yan, Hai
Tang, Naimei
Zou, Yi
Al-Hadeethi, Yas
Xu, Xiaochuan
Dalir, Hamed
Chen, Ray T.
Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
title Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
title_full Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
title_fullStr Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
title_full_unstemmed Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
title_short Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
title_sort ultra sensitivity silicon-based photonic crystal microcavity biosensors for plasma protein detection in patients with pancreatic cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142818/
https://www.ncbi.nlm.nih.gov/pubmed/32182956
http://dx.doi.org/10.3390/mi11030282
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