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Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability. Aberrant dynamic regulation of RNA N6-methyladenosine (m6A) h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Compuscript
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142843/ https://www.ncbi.nlm.nih.gov/pubmed/32296573 http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0347 |
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author | Liang, Zhixian Kidwell, Reilly L. Deng, Haijing Xie, Qi |
author_facet | Liang, Zhixian Kidwell, Reilly L. Deng, Haijing Xie, Qi |
author_sort | Liang, Zhixian |
collection | PubMed |
description | The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability. Aberrant dynamic regulation of RNA N6-methyladenosine (m6A) has been reported in numerous human diseases, including several cancers. In recent years, eukaryotic DNA N6-methyladenosine (6mA) has also been reported and implicated in cancer progression and tumorigenesis. In this review, we summarize the contributions of N6-methyladenosine modification to cancer biology and pathogenesis in the context of both RNA and DNA. We also highlight the clinical relevance of targeting these modifications as a therapeutic strategy for cancer. |
format | Online Article Text |
id | pubmed-7142843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Compuscript |
record_format | MEDLINE/PubMed |
spelling | pubmed-71428432020-04-15 Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer Liang, Zhixian Kidwell, Reilly L. Deng, Haijing Xie, Qi Cancer Biol Med Review The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability. Aberrant dynamic regulation of RNA N6-methyladenosine (m6A) has been reported in numerous human diseases, including several cancers. In recent years, eukaryotic DNA N6-methyladenosine (6mA) has also been reported and implicated in cancer progression and tumorigenesis. In this review, we summarize the contributions of N6-methyladenosine modification to cancer biology and pathogenesis in the context of both RNA and DNA. We also highlight the clinical relevance of targeting these modifications as a therapeutic strategy for cancer. Compuscript 2020-02-15 2020-02-15 /pmc/articles/PMC7142843/ /pubmed/32296573 http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0347 Text en Copyright: © 2020, Cancer Biology & Medicine http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Liang, Zhixian Kidwell, Reilly L. Deng, Haijing Xie, Qi Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer |
title | Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer |
title_full | Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer |
title_fullStr | Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer |
title_full_unstemmed | Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer |
title_short | Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer |
title_sort | epigenetic n6-methyladenosine modification of rna and dna regulates cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142843/ https://www.ncbi.nlm.nih.gov/pubmed/32296573 http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0347 |
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