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COX-2 as a potential biomarker and therapeutic target in melanoma

With a constantly increasing incidence, cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options. Melanoma is a model tumor in immuno-oncology. Inflammation represents an important hallmark of cancer capable of induc...

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Detalles Bibliográficos
Autores principales: Tudor, Diana Valentina, Bâldea, Ioana, Lupu, Mihai, Kacso, Teodor, Kutasi, Eniko, Hopârtean, Andreea, Stretea, Roland, Gabriela Filip, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142851/
https://www.ncbi.nlm.nih.gov/pubmed/32296574
http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0339
Descripción
Sumario:With a constantly increasing incidence, cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options. Melanoma is a model tumor in immuno-oncology. Inflammation represents an important hallmark of cancer capable of inducing and sustaining tumor development. The inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune destruction. Besides its role in proliferation, angiogenesis, and apoptosis, cyclooxygenase-2 (COX-2) is a well-known promoter of immune suppression in melanoma. COX-2 inhibitors are closely involved in this condition. This review attempts to answer two controversial questions: is COX-2 a valuable prognostic factor? Among all COX-2 inhibitors, is celecoxib a suitable adjuvant in melanoma therapy?