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Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China

Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility. It is the most prevalent chronic liver disease worldwide. With rapid lifestyle transitions, its prevalence wo...

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Autores principales: Li, Hongbin, Guo, Meihao, An, Zhen, Meng, Jun, Jiang, Jing, Song, Jie, Wu, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143027/
https://www.ncbi.nlm.nih.gov/pubmed/32168920
http://dx.doi.org/10.3390/ijerph17061818
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author Li, Hongbin
Guo, Meihao
An, Zhen
Meng, Jun
Jiang, Jing
Song, Jie
Wu, Weidong
author_facet Li, Hongbin
Guo, Meihao
An, Zhen
Meng, Jun
Jiang, Jing
Song, Jie
Wu, Weidong
author_sort Li, Hongbin
collection PubMed
description Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility. It is the most prevalent chronic liver disease worldwide. With rapid lifestyle transitions, its prevalence worldwide is increasing, and tremendous challenges in controlling this pandemic are arising. The objective of this study was to investigate the prevalence and risk factors of MAFLD in rural areas of Xinxiang, Henan in 2017. We conducted a cross-sectional analysis of rural inhabitants aged 20–79 years in Xinxiang, Henan in 2017, using cluster random sampling (N = 9140). Physical examinations were conducted at local clinics from April to June 2017. After overnight fasting, all participants underwent physical examinations, blood routine tests, biochemical examinations, and liver ultrasound and completed questionnaires. We investigated the crude and age-adjusted MAFLD prevalence and analyzed the characteristics of those with, and without, MAFLD, using logistic regression. Approximately 2868 (31.38%) participants were diagnosed with MAFLD. The overall age-adjusted MAFLD prevalence was 29.85% (men: 35.36%; women: 26.49%). The MAFLD prevalence increased with age, and peaked at the 50–59-year age group, and then began to decline. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were independently and positively correlated with MAFLD; In contrary, active physical activity and high-density lipoprotein cholesterol were negatively correlated with MAFLD. In summary, the MAFLD prevalence in the study population was 29.85%. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were risk factors for MAFLD.
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spelling pubmed-71430272020-04-14 Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China Li, Hongbin Guo, Meihao An, Zhen Meng, Jun Jiang, Jing Song, Jie Wu, Weidong Int J Environ Res Public Health Article Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and genetic susceptibility. It is the most prevalent chronic liver disease worldwide. With rapid lifestyle transitions, its prevalence worldwide is increasing, and tremendous challenges in controlling this pandemic are arising. The objective of this study was to investigate the prevalence and risk factors of MAFLD in rural areas of Xinxiang, Henan in 2017. We conducted a cross-sectional analysis of rural inhabitants aged 20–79 years in Xinxiang, Henan in 2017, using cluster random sampling (N = 9140). Physical examinations were conducted at local clinics from April to June 2017. After overnight fasting, all participants underwent physical examinations, blood routine tests, biochemical examinations, and liver ultrasound and completed questionnaires. We investigated the crude and age-adjusted MAFLD prevalence and analyzed the characteristics of those with, and without, MAFLD, using logistic regression. Approximately 2868 (31.38%) participants were diagnosed with MAFLD. The overall age-adjusted MAFLD prevalence was 29.85% (men: 35.36%; women: 26.49%). The MAFLD prevalence increased with age, and peaked at the 50–59-year age group, and then began to decline. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were independently and positively correlated with MAFLD; In contrary, active physical activity and high-density lipoprotein cholesterol were negatively correlated with MAFLD. In summary, the MAFLD prevalence in the study population was 29.85%. Higher body mass index, waist circumference, percentage of lymphocytes, levels of hemoglobin, platelet count, triglyceride, fasting plasma glucose, and serum uric acid were risk factors for MAFLD. MDPI 2020-03-11 2020-03 /pmc/articles/PMC7143027/ /pubmed/32168920 http://dx.doi.org/10.3390/ijerph17061818 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Hongbin
Guo, Meihao
An, Zhen
Meng, Jun
Jiang, Jing
Song, Jie
Wu, Weidong
Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
title Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
title_full Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
title_fullStr Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
title_full_unstemmed Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
title_short Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
title_sort prevalence and risk factors of metabolic associated fatty liver disease in xinxiang, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143027/
https://www.ncbi.nlm.nih.gov/pubmed/32168920
http://dx.doi.org/10.3390/ijerph17061818
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