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The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years,...

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Autores principales: Song, Kena, Li, Guoqiang, Zu, Xiangyang, Du, Zhe, Liu, Liyu, Hu, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143183/
https://www.ncbi.nlm.nih.gov/pubmed/32168977
http://dx.doi.org/10.3390/mi11030297
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author Song, Kena
Li, Guoqiang
Zu, Xiangyang
Du, Zhe
Liu, Liyu
Hu, Zhigang
author_facet Song, Kena
Li, Guoqiang
Zu, Xiangyang
Du, Zhe
Liu, Liyu
Hu, Zhigang
author_sort Song, Kena
collection PubMed
description Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.
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spelling pubmed-71431832020-04-14 The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review Song, Kena Li, Guoqiang Zu, Xiangyang Du, Zhe Liu, Liyu Hu, Zhigang Micromachines (Basel) Review Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future. MDPI 2020-03-11 /pmc/articles/PMC7143183/ /pubmed/32168977 http://dx.doi.org/10.3390/mi11030297 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Song, Kena
Li, Guoqiang
Zu, Xiangyang
Du, Zhe
Liu, Liyu
Hu, Zhigang
The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
title The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
title_full The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
title_fullStr The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
title_full_unstemmed The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
title_short The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
title_sort fabrication and application mechanism of microfluidic systems for high throughput biomedical screening: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143183/
https://www.ncbi.nlm.nih.gov/pubmed/32168977
http://dx.doi.org/10.3390/mi11030297
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