COVID-19: immunopathology and its implications for therapy

Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patie...

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Autor principal: Cao, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143200/
https://www.ncbi.nlm.nih.gov/pubmed/32273594
http://dx.doi.org/10.1038/s41577-020-0308-3
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author Cao, Xuetao
author_facet Cao, Xuetao
author_sort Cao, Xuetao
collection PubMed
description Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management.
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spelling pubmed-71432002020-04-09 COVID-19: immunopathology and its implications for therapy Cao, Xuetao Nat Rev Immunol Comment Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management. Nature Publishing Group UK 2020-04-09 2020 /pmc/articles/PMC7143200/ /pubmed/32273594 http://dx.doi.org/10.1038/s41577-020-0308-3 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Cao, Xuetao
COVID-19: immunopathology and its implications for therapy
title COVID-19: immunopathology and its implications for therapy
title_full COVID-19: immunopathology and its implications for therapy
title_fullStr COVID-19: immunopathology and its implications for therapy
title_full_unstemmed COVID-19: immunopathology and its implications for therapy
title_short COVID-19: immunopathology and its implications for therapy
title_sort covid-19: immunopathology and its implications for therapy
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143200/
https://www.ncbi.nlm.nih.gov/pubmed/32273594
http://dx.doi.org/10.1038/s41577-020-0308-3
work_keys_str_mv AT caoxuetao covid19immunopathologyanditsimplicationsfortherapy

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