Cargando…

A Phenotarget Approach for Identifying an Alkaloid Interacting with the Tuberculosis Protein Rv1466

In recent years, there has been a revival of interest in phenotypic-based drug discovery (PDD) due to target-based drug discovery (TDD) falling below expectations. Both PDD and TDD have their unique advantages and should be used as complementary methods in drug discovery. The PhenoTarget approach co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Yan, Feng, Yunjiang, Di Capua, Angela, Mak, Tin, Buchko, Garry W., Myler, Peter J., Liu, Miaomiao, Quinn, Ronald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143284/ https://www.ncbi.nlm.nih.gov/pubmed/32150903 http://dx.doi.org/10.3390/md18030149

Ejemplares similares

Discovery of a Natural Product That Binds to the Mycobacterium tuberculosis Protein Rv1466 Using Native Mass Spectrometry
por: Elnaas, Ali R., et al.
Publicado: (2020)

Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis
por: Buchko, Garry W., et al.
Publicado: (2011)

Donatello 1386-1466 /
por: Wirtz, Rolf C. 1964-
Publicado: (1998)

Antimicrobial Benzyltetrahydroisoquinoline-Derived Alkaloids from the Leaves of Doryphora aromatica
por: Liu, Miaomiao, et al.
Publicado: (2021)

Crystal structure of a hemerythrin-like protein from Mycobacterium kansasii and homology model of the orthologous Rv2633c protein of M. tuberculosis
por: Ma, Zhongxin, et al.
Publicado: (2020)

Evaluation of Rv0220, Rv2958c, Rv2994 and Rv3347c of Mycobacterium tuberculosis for serodiagnosis of tuberculosis
por: You, Xiaolong, et al.
Publicado: (2017)

Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis
por: Peterson, Eliza J.R., et al.
Publicado: (2016)

1466. Alkaline Urine: A Cause for Urinary Tract Infection Recurrence
por: Wattengel, Bethany A, et al.
Publicado: (2019)

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection
por: Kimuda, Simon G., et al.
Publicado: (2017)

1466 Primary Cutaneous Mold Infections in Hematologic Malignancy with a Review of the Literature
por: Mai, Jane, et al.
Publicado: (2014)

1466. Antibiotic utilization reports may reduce prescribing practices for Upper Respiratory Infections
por: Salcedo, David Augusto Terrero, et al.
Publicado: (2020)

Backbone chemical shift assignments for the SARS-CoV-2 non-structural protein Nsp9: intermediate (ms – μs) dynamics in the C-terminal helix at the dimer interface
por: Buchko, Garry W., et al.
Publicado: (2021)

Rv2031c of Mycobacterium tuberculosis: a master regulator of Rv2028–Rv2031 (HspX) operon
por: Mushtaq, Khurram, et al.
Publicado: (2015)

Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis
por: Buchko, Garry W., et al.
Publicado: (2011)

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates
por: Shahi, Fatemeh, et al.
Publicado: (2021)

Unusual Findings in Appendectomy Specimens of Adults: Retrospective Analyses of 1466 Patients and a Review of Literature
por: Yabanoglu, Hakan, et al.
Publicado: (2014)

Systematic Evaluation of Mycobacterium tuberculosis Proteins for Antigenic Properties Identifies Rv1485 and Rv1705c as Potential Protective Subunit Vaccine Candidates
por: Wang, Yaguo, et al.
Publicado: (2021)

Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis
por: Gomez, Andromeda, et al.
Publicado: (2016)

Enhanced serodiagnostic potential of a fusion molecule consisting of Rv1793, Rv2628 and a truncated Rv2608 of Mycobacterium tuberculosis
por: Sulman, Sadaf, et al.
Publicado: (2021)

Collision-Induced Affinity Selection Mass Spectrometry for Identification of Ligands
por: Mak, Tin, et al.
Publicado: (2022)

The Rv3874-Rv3875 chimeric protein shows a promiscuous serodiagnostic potential for tuberculosis
por: Mahmood, Nasir, et al.
Publicado: (2022)

A prediction model for sulcus-to-sulcus diameter in myopic eyes: a 1466-sample retrospective study
por: Zhu, Qiu-Jian, et al.
Publicado: (2022)

P1466: CD7 CHIMERIC ANTIGEN RECEPTOR T CELLS FOR ADULT PATIENTS WITH REFRACTORY AND RELAPSED T CELL MALIGNANCIES
por: Zhang, Y., et al.
Publicado: (2022)

Use of Rv0222-Rv2657c-Rv1509 Fusion Protein to Improve the Accuracy of an Antibody ELISA for Extra-Pulmonary Tuberculosis in Humans
por: Chen, Yingyu, et al.
Publicado: (2021)

Mycobacterium tuberculosis Rv0494 Protein Contributes to Mycobacterial Persistence
por: Ji, Lei, et al.
Publicado: (2023)

Transcription factors Rv0081 and Rv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis
por: Sun, Xian, et al.
Publicado: (2018)

Erratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456–1466
por: Dashti, Hassan S., et al.
Publicado: (2017)

Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis
por: Zhang, Lei, et al.
Publicado: (2023)

Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c Proteins Participate in the Suppression of Macrophage Apoptosis
por: Danelishvili, Lia, et al.
Publicado: (2010)

Antigens Rv0310c and Rv1255c are promising novel biomarkers for the diagnosis of Mycobacterium tuberculosis infection
por: Luo, Liulin, et al.
Publicado: (2017)

MiaA (Rv2727c) mediated tRNA isopentenylation of Mycobacterium tuberculosis H37Rv
por: Soman, Smitha, et al.
Publicado: (2022)

P1466: EFFECT OF LUSPATERCEPT ON BONE MINERAL DENSITY IN PATIENTS WITH BETA‑THALASSEMIA ENROLLED IN THE PHASE 3 BELIEVE TRIAL
por: Coates, Thomas D., et al.
Publicado: (2023)

Comparative Genome and Network Centrality Analysis to Identify Drug Targets of Mycobacterium tuberculosis H37Rv
por: Melak, Tilahun, et al.
Publicado: (2015)

The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
por: Ramulu, Hemalatha G., et al.
Publicado: (2007)

The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages
por: Tiwari, Bhavana Mishra, et al.
Publicado: (2012)

Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis
por: Zhao, Nan, et al.
Publicado: (2015)

1466. Adherence to Empiric Treatment Recommended by IDSA/PIDS Pediatric Community-Acquired Pneumonia (CAP) Guidelines According to Immunization Status
por: Thomas, Lindsay, et al.
Publicado: (2018)

Protective Efficacy and Immunogenicity of Rv0351/Rv3628 Subunit Vaccine Formulated in Different Adjuvants Against Mycobacterium tuberculosis Infection
por: Kwon, Kee Woong, et al.
Publicado: (2023)

Comparing mRNA expression and protein abundance in MDR Mycobacterium tuberculosis: Novel protein candidates, Rv0443, Rv0379 and Rv0147 as TB potential diagnostic or therapeutic targets
por: Hadizadeh Tasbiti, Alireza, et al.
Publicado: (2021)

Structural Prediction and Mutational Analysis of Rv3906c Gene of Mycobacterium tuberculosis H(37)Rv to Determine Its Essentiality in Survival
por: Beg, Md. Amjad, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bc13vivvifkhnaip596afsc323