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Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite

Magnesium (Mg) alloys are being investigated as a biodegradable metallic biomaterial because of their mechanical property profile, which is similar to the human bone. However, implants based on Mg alloys are corroded quickly in the body before the bone fracture is fully healed. Therefore, we aimed t...

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Autores principales: Razavi, Mehdi, Fathi, Mohammadhossein, Savabi, Omid, Tayebi, Lobat, Vashaee, Daryoosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143302/
https://www.ncbi.nlm.nih.gov/pubmed/32183231
http://dx.doi.org/10.3390/ma13061315
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author Razavi, Mehdi
Fathi, Mohammadhossein
Savabi, Omid
Tayebi, Lobat
Vashaee, Daryoosh
author_facet Razavi, Mehdi
Fathi, Mohammadhossein
Savabi, Omid
Tayebi, Lobat
Vashaee, Daryoosh
author_sort Razavi, Mehdi
collection PubMed
description Magnesium (Mg) alloys are being investigated as a biodegradable metallic biomaterial because of their mechanical property profile, which is similar to the human bone. However, implants based on Mg alloys are corroded quickly in the body before the bone fracture is fully healed. Therefore, we aimed to reduce the corrosion rate of Mg using a double protective layer. We used a magnesium-aluminum-zinc alloy (AZ91) and treated its surface with micro-arc oxidation (MAO) technique to first form an intermediate layer. Next, a bioceramic nanocomposite composed of diopside, bredigite, and fluoridated hydroxyapatite (FHA) was coated on the surface of MAO treated AZ91 using the electrophoretic deposition (EPD) technique. Our in vivo results showed a significant enhancement in the bioactivity of the nanocomposite coated AZ91 implant compared to the uncoated control implant. Implantation of the uncoated AZ91 caused a significant release of hydrogen bubbles around the implant, which was reduced when the nanocomposite coated implants were used. Using histology, this reduction in the corrosion rate of the coated implants resulted in an improved new bone formation and reduced inflammation in the interface of the implants and the surrounding tissue. Hence, our strategy using a MAO/EPD of a bioceramic nanocomposite coating (i.e., diopside-bredigite-FHA) can significantly reduce the corrosion rate and improve the bioactivity of the biodegradable AZ91 Mg implant.
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spelling pubmed-71433022020-04-14 Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite Razavi, Mehdi Fathi, Mohammadhossein Savabi, Omid Tayebi, Lobat Vashaee, Daryoosh Materials (Basel) Article Magnesium (Mg) alloys are being investigated as a biodegradable metallic biomaterial because of their mechanical property profile, which is similar to the human bone. However, implants based on Mg alloys are corroded quickly in the body before the bone fracture is fully healed. Therefore, we aimed to reduce the corrosion rate of Mg using a double protective layer. We used a magnesium-aluminum-zinc alloy (AZ91) and treated its surface with micro-arc oxidation (MAO) technique to first form an intermediate layer. Next, a bioceramic nanocomposite composed of diopside, bredigite, and fluoridated hydroxyapatite (FHA) was coated on the surface of MAO treated AZ91 using the electrophoretic deposition (EPD) technique. Our in vivo results showed a significant enhancement in the bioactivity of the nanocomposite coated AZ91 implant compared to the uncoated control implant. Implantation of the uncoated AZ91 caused a significant release of hydrogen bubbles around the implant, which was reduced when the nanocomposite coated implants were used. Using histology, this reduction in the corrosion rate of the coated implants resulted in an improved new bone formation and reduced inflammation in the interface of the implants and the surrounding tissue. Hence, our strategy using a MAO/EPD of a bioceramic nanocomposite coating (i.e., diopside-bredigite-FHA) can significantly reduce the corrosion rate and improve the bioactivity of the biodegradable AZ91 Mg implant. MDPI 2020-03-13 /pmc/articles/PMC7143302/ /pubmed/32183231 http://dx.doi.org/10.3390/ma13061315 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Razavi, Mehdi
Fathi, Mohammadhossein
Savabi, Omid
Tayebi, Lobat
Vashaee, Daryoosh
Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite
title Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite
title_full Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite
title_fullStr Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite
title_full_unstemmed Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite
title_short Biodegradable Magnesium Bone Implants Coated with a Novel Bioceramic Nanocomposite
title_sort biodegradable magnesium bone implants coated with a novel bioceramic nanocomposite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143302/
https://www.ncbi.nlm.nih.gov/pubmed/32183231
http://dx.doi.org/10.3390/ma13061315
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