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Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring

[Image: see text] We have developed a rapid and sensitive single-well dual-parametric method introduced in linked RAS nucleotide exchange and RAS/RAF-RBD interaction assays. RAS mutations are frequent drivers of multiple different human cancers, but the development of therapeutic strategies has been...

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Detalles Bibliográficos
Autores principales:	Kopra, Kari, Vuorinen, Emmiliisa, Abreu-Blanco, Maria, Wang, Qi, Eskonen, Ville, Gillette, William, Pulliainen, Arto T., Holderfield, Matthew, Härmä, Harri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143314/ https://www.ncbi.nlm.nih.gov/pubmed/32106676 http://dx.doi.org/10.1021/acs.analchem.9b05126

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