Cargando…

Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study

Background and objectives: Although laparoscopic sleeve gastrectomy (LSG) is effective for obesity management, postoperative vitamin B12 (B12) deficiency is of major concern. In this cross-sectional study, we assessed the levels of B12 and its related functional biomarkers, namely, total homocystein...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Dirbashi, Osama Y., Sharma, Charu, Al Dahouri, Nahid, Al Aidaros, Anas, Al-Muhairi, Shamma, Beiram, Rami, Gariballa, Salah, Al Kaabi, Juma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143905/
https://www.ncbi.nlm.nih.gov/pubmed/32245061
http://dx.doi.org/10.3390/medicina56030142
_version_ 1783519723027169280
author Al-Dirbashi, Osama Y.
Sharma, Charu
Al Dahouri, Nahid
Al Aidaros, Anas
Al-Muhairi, Shamma
Beiram, Rami
Gariballa, Salah
Al Kaabi, Juma
author_facet Al-Dirbashi, Osama Y.
Sharma, Charu
Al Dahouri, Nahid
Al Aidaros, Anas
Al-Muhairi, Shamma
Beiram, Rami
Gariballa, Salah
Al Kaabi, Juma
author_sort Al-Dirbashi, Osama Y.
collection PubMed
description Background and objectives: Although laparoscopic sleeve gastrectomy (LSG) is effective for obesity management, postoperative vitamin B12 (B12) deficiency is of major concern. In this cross-sectional study, we assessed the levels of B12 and its related functional biomarkers, namely, total homocysteine (tHcy), methylmalonic acid (MMA), folate, methylcitric acid (MCA), and hemoglobin (Hb), in one-year postoperative LSG patients and matched controls. Materials and Methods: Plasma B12, tHcy, MMA, folate, and MCA were measured in matched controls (n = 66) and patients (n = 71) using validated liquid chromatography-tandem mass spectrometry techniques and protocols in the United Arab Emirates (UAE). Results: The median B12 concentration in patients (177 pmol/L) was significantly lower (p < 0.001) than in the controls (334.7 pmol/L). The tHcy and MMA levels were significantly increased (p < 0.001 and p = 0.011, respectively) and folate levels were significantly decreased (p = 0.001) in the LSG patients compared to the controls. Interestingly, no significant difference in MCA levels were observed between the two groups. The levels of tHcy and MMA were concomitantly increased with the decreased folate levels in postoperative LSG patients when compared with the controls. The Hb levels were significantly lower in males and females in the patient group compared with those in the control group, respectively (p = 0.005 and p = 0.043). Conclusions: This is the first report of serum levels of B12 and its functional biomarkers in postoperative LSG patients among a local population from the UAE. Our findings revealed significant alterations of the B12 biomarkers, total B12, MMA, and tHcy in one-year postoperative LSG patients.
format Online
Article
Text
id pubmed-7143905
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71439052020-04-14 Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study Al-Dirbashi, Osama Y. Sharma, Charu Al Dahouri, Nahid Al Aidaros, Anas Al-Muhairi, Shamma Beiram, Rami Gariballa, Salah Al Kaabi, Juma Medicina (Kaunas) Article Background and objectives: Although laparoscopic sleeve gastrectomy (LSG) is effective for obesity management, postoperative vitamin B12 (B12) deficiency is of major concern. In this cross-sectional study, we assessed the levels of B12 and its related functional biomarkers, namely, total homocysteine (tHcy), methylmalonic acid (MMA), folate, methylcitric acid (MCA), and hemoglobin (Hb), in one-year postoperative LSG patients and matched controls. Materials and Methods: Plasma B12, tHcy, MMA, folate, and MCA were measured in matched controls (n = 66) and patients (n = 71) using validated liquid chromatography-tandem mass spectrometry techniques and protocols in the United Arab Emirates (UAE). Results: The median B12 concentration in patients (177 pmol/L) was significantly lower (p < 0.001) than in the controls (334.7 pmol/L). The tHcy and MMA levels were significantly increased (p < 0.001 and p = 0.011, respectively) and folate levels were significantly decreased (p = 0.001) in the LSG patients compared to the controls. Interestingly, no significant difference in MCA levels were observed between the two groups. The levels of tHcy and MMA were concomitantly increased with the decreased folate levels in postoperative LSG patients when compared with the controls. The Hb levels were significantly lower in males and females in the patient group compared with those in the control group, respectively (p = 0.005 and p = 0.043). Conclusions: This is the first report of serum levels of B12 and its functional biomarkers in postoperative LSG patients among a local population from the UAE. Our findings revealed significant alterations of the B12 biomarkers, total B12, MMA, and tHcy in one-year postoperative LSG patients. MDPI 2020-03-20 /pmc/articles/PMC7143905/ /pubmed/32245061 http://dx.doi.org/10.3390/medicina56030142 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Dirbashi, Osama Y.
Sharma, Charu
Al Dahouri, Nahid
Al Aidaros, Anas
Al-Muhairi, Shamma
Beiram, Rami
Gariballa, Salah
Al Kaabi, Juma
Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study
title Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study
title_full Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study
title_fullStr Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study
title_full_unstemmed Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study
title_short Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study
title_sort role of functional biomarkers to identify early vitamin b12 deficiency in patients with sleeve gastrectomy: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143905/
https://www.ncbi.nlm.nih.gov/pubmed/32245061
http://dx.doi.org/10.3390/medicina56030142
work_keys_str_mv AT aldirbashiosamay roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT sharmacharu roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT aldahourinahid roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT alaidarosanas roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT almuhairishamma roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT beiramrami roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT gariballasalah roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy
AT alkaabijuma roleoffunctionalbiomarkerstoidentifyearlyvitaminb12deficiencyinpatientswithsleevegastrectomyacrosssectionalstudy