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The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143985/ https://www.ncbi.nlm.nih.gov/pubmed/32204328 http://dx.doi.org/10.3390/microorganisms8030431 |
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author | Campisciano, Giuseppina de Manzini, Nicolò Delbue, Serena Cason, Carolina Cosola, Davide Basile, Giuseppe Ferrante, Pasquale Comar, Manola Palmisano, Silvia |
author_facet | Campisciano, Giuseppina de Manzini, Nicolò Delbue, Serena Cason, Carolina Cosola, Davide Basile, Giuseppe Ferrante, Pasquale Comar, Manola Palmisano, Silvia |
author_sort | Campisciano, Giuseppina |
collection | PubMed |
description | An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation. |
format | Online Article Text |
id | pubmed-7143985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71439852020-04-13 The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development Campisciano, Giuseppina de Manzini, Nicolò Delbue, Serena Cason, Carolina Cosola, Davide Basile, Giuseppe Ferrante, Pasquale Comar, Manola Palmisano, Silvia Microorganisms Article An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation. MDPI 2020-03-19 /pmc/articles/PMC7143985/ /pubmed/32204328 http://dx.doi.org/10.3390/microorganisms8030431 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Campisciano, Giuseppina de Manzini, Nicolò Delbue, Serena Cason, Carolina Cosola, Davide Basile, Giuseppe Ferrante, Pasquale Comar, Manola Palmisano, Silvia The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development |
title | The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development |
title_full | The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development |
title_fullStr | The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development |
title_full_unstemmed | The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development |
title_short | The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development |
title_sort | obesity-related gut bacterial and viral dysbiosis can impact the risk of colon cancer development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143985/ https://www.ncbi.nlm.nih.gov/pubmed/32204328 http://dx.doi.org/10.3390/microorganisms8030431 |
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