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The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development

An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colo...

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Autores principales: Campisciano, Giuseppina, de Manzini, Nicolò, Delbue, Serena, Cason, Carolina, Cosola, Davide, Basile, Giuseppe, Ferrante, Pasquale, Comar, Manola, Palmisano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143985/
https://www.ncbi.nlm.nih.gov/pubmed/32204328
http://dx.doi.org/10.3390/microorganisms8030431
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author Campisciano, Giuseppina
de Manzini, Nicolò
Delbue, Serena
Cason, Carolina
Cosola, Davide
Basile, Giuseppe
Ferrante, Pasquale
Comar, Manola
Palmisano, Silvia
author_facet Campisciano, Giuseppina
de Manzini, Nicolò
Delbue, Serena
Cason, Carolina
Cosola, Davide
Basile, Giuseppe
Ferrante, Pasquale
Comar, Manola
Palmisano, Silvia
author_sort Campisciano, Giuseppina
collection PubMed
description An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation.
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spelling pubmed-71439852020-04-13 The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development Campisciano, Giuseppina de Manzini, Nicolò Delbue, Serena Cason, Carolina Cosola, Davide Basile, Giuseppe Ferrante, Pasquale Comar, Manola Palmisano, Silvia Microorganisms Article An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation. MDPI 2020-03-19 /pmc/articles/PMC7143985/ /pubmed/32204328 http://dx.doi.org/10.3390/microorganisms8030431 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campisciano, Giuseppina
de Manzini, Nicolò
Delbue, Serena
Cason, Carolina
Cosola, Davide
Basile, Giuseppe
Ferrante, Pasquale
Comar, Manola
Palmisano, Silvia
The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
title The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
title_full The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
title_fullStr The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
title_full_unstemmed The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
title_short The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development
title_sort obesity-related gut bacterial and viral dysbiosis can impact the risk of colon cancer development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143985/
https://www.ncbi.nlm.nih.gov/pubmed/32204328
http://dx.doi.org/10.3390/microorganisms8030431
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