Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

The bovine viral diarrhea virus (BVDV), a pestivirus from the family of Flaviviridae is ubiquitous and causes a range of clinical manifestations in livestock, mainly cattle. Two quinolinecarboxamide analogues were identified in a CPE-based screening effort, as selective inhibitors of the in vitro bo...

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Detalles Bibliográficos
Autores principales: Musiu, Simone, Castillo, Yunierkis Perez, Muigg, Alexandra, Pürstinger, Gerhard, Leyssen, Pieter, Froeyen, Mathy, Neyts, Johan, Paeshuyse, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144022/
https://www.ncbi.nlm.nih.gov/pubmed/32178258
http://dx.doi.org/10.3390/molecules25061283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144022/
https://www.ncbi.nlm.nih.gov/pubmed/32178258
http://dx.doi.org/10.3390/molecules25061283

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