Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

BACKGROUND: Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression...

Descripción completa

Detalles Bibliográficos
Autores principales: Santana, Magda M., Paixão, Susana, Cunha-Santos, Janete, Silva, Teresa Pereira, Trevino-Garcia, Allyson, Gaspar, Laetitia S., Nóbrega, Clévio, Nobre, Rui Jorge, Cavadas, Cláudia, Greif, Hagar, Pereira de Almeida, Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144062/
https://www.ncbi.nlm.nih.gov/pubmed/32272938
http://dx.doi.org/10.1186/s12967-020-02302-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144062/
https://www.ncbi.nlm.nih.gov/pubmed/32272938
http://dx.doi.org/10.1186/s12967-020-02302-2

Ejemplares similares