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RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1

The Hippo pathway regulates growth and apoptosis. We identify RhoBTB proteins as novel regulators of Hippo signaling. RhoBTB depletion in the Drosophila wing disc epithelium cooperated with Yki to drive hyperplasia into neoplasia. Depletion of RhoBTB2 caused elevated YAP activity in human cells. Rho...

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Detalles Bibliográficos
Autores principales:	Nguyen, Thanh Hung, Ralbovska, Adela, Kugler, Jan-Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2020
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144079/ https://www.ncbi.nlm.nih.gov/pubmed/32111652 http://dx.doi.org/10.1534/g3.120.401038

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