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Natural and Biomimetic Antitumor Pyrazoles, A Perspective
The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144110/ https://www.ncbi.nlm.nih.gov/pubmed/32192149 http://dx.doi.org/10.3390/molecules25061364 |
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author | Santos, Nádia E. Carreira, Ana R.F. Silva, Vera L. M. Braga, Susana Santos |
author_facet | Santos, Nádia E. Carreira, Ana R.F. Silva, Vera L. M. Braga, Susana Santos |
author_sort | Santos, Nádia E. |
collection | PubMed |
description | The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated in 1969, and a few others have been reported since then, most of them in the last decade. This paper presents a perspective on the current knowledge on antitumor natural pyrazoles, organized into two sections. The first focuses on the three known families of cytotoxic pyrazoles that were directly isolated from plants, for which the knowledge of the medicinal properties is in its infancy. The second section describes pyrazole derivatives of natural products, discussing their structure–activity relationships. |
format | Online Article Text |
id | pubmed-7144110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71441102020-04-13 Natural and Biomimetic Antitumor Pyrazoles, A Perspective Santos, Nádia E. Carreira, Ana R.F. Silva, Vera L. M. Braga, Susana Santos Molecules Review The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated in 1969, and a few others have been reported since then, most of them in the last decade. This paper presents a perspective on the current knowledge on antitumor natural pyrazoles, organized into two sections. The first focuses on the three known families of cytotoxic pyrazoles that were directly isolated from plants, for which the knowledge of the medicinal properties is in its infancy. The second section describes pyrazole derivatives of natural products, discussing their structure–activity relationships. MDPI 2020-03-17 /pmc/articles/PMC7144110/ /pubmed/32192149 http://dx.doi.org/10.3390/molecules25061364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Santos, Nádia E. Carreira, Ana R.F. Silva, Vera L. M. Braga, Susana Santos Natural and Biomimetic Antitumor Pyrazoles, A Perspective |
title | Natural and Biomimetic Antitumor Pyrazoles, A Perspective |
title_full | Natural and Biomimetic Antitumor Pyrazoles, A Perspective |
title_fullStr | Natural and Biomimetic Antitumor Pyrazoles, A Perspective |
title_full_unstemmed | Natural and Biomimetic Antitumor Pyrazoles, A Perspective |
title_short | Natural and Biomimetic Antitumor Pyrazoles, A Perspective |
title_sort | natural and biomimetic antitumor pyrazoles, a perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144110/ https://www.ncbi.nlm.nih.gov/pubmed/32192149 http://dx.doi.org/10.3390/molecules25061364 |
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