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Natural and Biomimetic Antitumor Pyrazoles, A Perspective

The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated...

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Detalles Bibliográficos
Autores principales: Santos, Nádia E., Carreira, Ana R.F., Silva, Vera L. M., Braga, Susana Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144110/
https://www.ncbi.nlm.nih.gov/pubmed/32192149
http://dx.doi.org/10.3390/molecules25061364
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author Santos, Nádia E.
Carreira, Ana R.F.
Silva, Vera L. M.
Braga, Susana Santos
author_facet Santos, Nádia E.
Carreira, Ana R.F.
Silva, Vera L. M.
Braga, Susana Santos
author_sort Santos, Nádia E.
collection PubMed
description The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated in 1969, and a few others have been reported since then, most of them in the last decade. This paper presents a perspective on the current knowledge on antitumor natural pyrazoles, organized into two sections. The first focuses on the three known families of cytotoxic pyrazoles that were directly isolated from plants, for which the knowledge of the medicinal properties is in its infancy. The second section describes pyrazole derivatives of natural products, discussing their structure–activity relationships.
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spelling pubmed-71441102020-04-13 Natural and Biomimetic Antitumor Pyrazoles, A Perspective Santos, Nádia E. Carreira, Ana R.F. Silva, Vera L. M. Braga, Susana Santos Molecules Review The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated in 1969, and a few others have been reported since then, most of them in the last decade. This paper presents a perspective on the current knowledge on antitumor natural pyrazoles, organized into two sections. The first focuses on the three known families of cytotoxic pyrazoles that were directly isolated from plants, for which the knowledge of the medicinal properties is in its infancy. The second section describes pyrazole derivatives of natural products, discussing their structure–activity relationships. MDPI 2020-03-17 /pmc/articles/PMC7144110/ /pubmed/32192149 http://dx.doi.org/10.3390/molecules25061364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Santos, Nádia E.
Carreira, Ana R.F.
Silva, Vera L. M.
Braga, Susana Santos
Natural and Biomimetic Antitumor Pyrazoles, A Perspective
title Natural and Biomimetic Antitumor Pyrazoles, A Perspective
title_full Natural and Biomimetic Antitumor Pyrazoles, A Perspective
title_fullStr Natural and Biomimetic Antitumor Pyrazoles, A Perspective
title_full_unstemmed Natural and Biomimetic Antitumor Pyrazoles, A Perspective
title_short Natural and Biomimetic Antitumor Pyrazoles, A Perspective
title_sort natural and biomimetic antitumor pyrazoles, a perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144110/
https://www.ncbi.nlm.nih.gov/pubmed/32192149
http://dx.doi.org/10.3390/molecules25061364
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