Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca(2+) channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate MTDLs 3a–t, resulting from the ju...

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Detalles Bibliográficos
Autores principales: Pachòn Angona, Irene, Daniel, Solene, Martin, Helene, Bonet, Alexandre, Wnorowski, Artur, Maj, Maciej, Jóźwiak, Krzysztof, Silva, Tiago Barros, Refouvelet, Bernard, Borges, Fernanda, Marco-Contelles, José, Ismaili, Lhassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144121/
https://www.ncbi.nlm.nih.gov/pubmed/32183349
http://dx.doi.org/10.3390/molecules25061329

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