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Development of a risk score for scoliosis in children with cerebral palsy
Background and purpose — Children and young adults with cerebral palsy (CP) have an increased risk of developing scoliosis, with a prevalence ranging from 11% to 29%. Information on risk factors for the emergence and progression of scoliosis is inconclusive. This study aimed to develop a risk score...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144338/ https://www.ncbi.nlm.nih.gov/pubmed/31928285 http://dx.doi.org/10.1080/17453674.2020.1711621 |
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author | Pettersson, Katina Wagner, Philippe Rodby-Bousquet, Elisabet |
author_facet | Pettersson, Katina Wagner, Philippe Rodby-Bousquet, Elisabet |
author_sort | Pettersson, Katina |
collection | PubMed |
description | Background and purpose — Children and young adults with cerebral palsy (CP) have an increased risk of developing scoliosis, with a prevalence ranging from 11% to 29%. Information on risk factors for the emergence and progression of scoliosis is inconclusive. This study aimed to develop a risk score based on 5-year-old children with CP to predict the risk of scoliosis before the age of 16. Patients and methods — This prospective registry study included 654 children with CP in Sweden born in 2000 to 2003 and registered with the Swedish CP follow-up program (CPUP) at the age of 5 years, including all Gross Motor Function Classification System (GMFCS) levels. 92 children developed a scoliosis before the age of 16 years. Univariable and multivariable logistic regressions were used to analyze 8 potential predictors for scoliosis: GMFCS, sex, spastic subtype, epilepsy, hip surgery, migration percentage, and limited hip or knee extension. Results — 4 predictors for scoliosis remained significant after analyses: female sex, GMFCS levels IV and V, epilepsy, and limited knee extension, and a risk score was constructed based on these factors. The predictive ability of the risk score was high, with an area under the receiver operating characteristics curve of 0.87 (95% CI 0.84–0.91). Interpretation — The risk score shows high discriminatory ability for differentiating between individuals at high and low risk for development of scoliosis before the age of 16. It may be useful when considering interventions to prevent or predict severe scoliosis in young children with CP. |
format | Online Article Text |
id | pubmed-7144338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-71443382020-04-13 Development of a risk score for scoliosis in children with cerebral palsy Pettersson, Katina Wagner, Philippe Rodby-Bousquet, Elisabet Acta Orthop Articles Background and purpose — Children and young adults with cerebral palsy (CP) have an increased risk of developing scoliosis, with a prevalence ranging from 11% to 29%. Information on risk factors for the emergence and progression of scoliosis is inconclusive. This study aimed to develop a risk score based on 5-year-old children with CP to predict the risk of scoliosis before the age of 16. Patients and methods — This prospective registry study included 654 children with CP in Sweden born in 2000 to 2003 and registered with the Swedish CP follow-up program (CPUP) at the age of 5 years, including all Gross Motor Function Classification System (GMFCS) levels. 92 children developed a scoliosis before the age of 16 years. Univariable and multivariable logistic regressions were used to analyze 8 potential predictors for scoliosis: GMFCS, sex, spastic subtype, epilepsy, hip surgery, migration percentage, and limited hip or knee extension. Results — 4 predictors for scoliosis remained significant after analyses: female sex, GMFCS levels IV and V, epilepsy, and limited knee extension, and a risk score was constructed based on these factors. The predictive ability of the risk score was high, with an area under the receiver operating characteristics curve of 0.87 (95% CI 0.84–0.91). Interpretation — The risk score shows high discriminatory ability for differentiating between individuals at high and low risk for development of scoliosis before the age of 16. It may be useful when considering interventions to prevent or predict severe scoliosis in young children with CP. Taylor & Francis 2020-01-13 /pmc/articles/PMC7144338/ /pubmed/31928285 http://dx.doi.org/10.1080/17453674.2020.1711621 Text en © 2020 The Author(s). Published by Taylor & Francis on behalf of the Nordic Orthopedic Federation https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Pettersson, Katina Wagner, Philippe Rodby-Bousquet, Elisabet Development of a risk score for scoliosis in children with cerebral palsy |
title | Development of a risk score for scoliosis in children with cerebral palsy |
title_full | Development of a risk score for scoliosis in children with cerebral palsy |
title_fullStr | Development of a risk score for scoliosis in children with cerebral palsy |
title_full_unstemmed | Development of a risk score for scoliosis in children with cerebral palsy |
title_short | Development of a risk score for scoliosis in children with cerebral palsy |
title_sort | development of a risk score for scoliosis in children with cerebral palsy |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144338/ https://www.ncbi.nlm.nih.gov/pubmed/31928285 http://dx.doi.org/10.1080/17453674.2020.1711621 |
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