Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae)

Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D an...

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Detalles Bibliográficos
Autores principales: Huynh, Thanh-Hao, Fang, Lee-Shing, Chen, Yu-Hsin, Peng, Bo-Rong, Chen, You-Ying, Zheng, Li-Guo, Wu, Yu-Jen, Wen, Zhi-Hong, Chen, Jih-Jung, Lin, Tzu-Chi, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144368/
https://www.ncbi.nlm.nih.gov/pubmed/32204524
http://dx.doi.org/10.3390/molecules25061405
Descripción
Sumario:Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

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