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Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae)
Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D an...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144368/ https://www.ncbi.nlm.nih.gov/pubmed/32204524 http://dx.doi.org/10.3390/molecules25061405 |
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| author | Huynh, Thanh-Hao Fang, Lee-Shing Chen, Yu-Hsin Peng, Bo-Rong Chen, You-Ying Zheng, Li-Guo Wu, Yu-Jen Wen, Zhi-Hong Chen, Jih-Jung Lin, Tzu-Chi Sung, Ping-Jyun |
| author_facet | Huynh, Thanh-Hao Fang, Lee-Shing Chen, Yu-Hsin Peng, Bo-Rong Chen, You-Ying Zheng, Li-Guo Wu, Yu-Jen Wen, Zhi-Hong Chen, Jih-Jung Lin, Tzu-Chi Sung, Ping-Jyun |
| author_sort | Huynh, Thanh-Hao |
| collection | PubMed |
| description | Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7. |
| format | Online Article Text |
| id | pubmed-7144368 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71443682020-04-13 Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) Huynh, Thanh-Hao Fang, Lee-Shing Chen, Yu-Hsin Peng, Bo-Rong Chen, You-Ying Zheng, Li-Guo Wu, Yu-Jen Wen, Zhi-Hong Chen, Jih-Jung Lin, Tzu-Chi Sung, Ping-Jyun Molecules Article Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7. MDPI 2020-03-19 /pmc/articles/PMC7144368/ /pubmed/32204524 http://dx.doi.org/10.3390/molecules25061405 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Huynh, Thanh-Hao Fang, Lee-Shing Chen, Yu-Hsin Peng, Bo-Rong Chen, You-Ying Zheng, Li-Guo Wu, Yu-Jen Wen, Zhi-Hong Chen, Jih-Jung Lin, Tzu-Chi Sung, Ping-Jyun Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) |
| title | Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) |
| title_full | Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) |
| title_fullStr | Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) |
| title_full_unstemmed | Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) |
| title_short | Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae) |
| title_sort | briarenols i—k, new anti-inflammatory 8,17-epoxybriaranes from the octocoral briareum excavatum (briareidae) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144368/ https://www.ncbi.nlm.nih.gov/pubmed/32204524 http://dx.doi.org/10.3390/molecules25061405 |
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