Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains poorly understood. Here, we show that the E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose of LPS v...

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Detalles Bibliográficos
Autores principales: Tang, Juan, Tu, Sha, Lin, Guoxin, Guo, Hui, Yan, Chengkai, Liu, Qingjun, Huang, Ling, Tang, Na, Xiao, Yizhi, Pope, R. Marshall, Rajaram, Murugesan V.S., Amer, Amal O., Ahmer, Brian M., Gunn, John S., Wozniak, Daniel J., Tao, Lijian, Coppola, Vincenzo, Zhang, Liwen, Langdon, Wallace Y., Torrelles, Jordi B., Lipkowitz, Stanley, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144527/
https://www.ncbi.nlm.nih.gov/pubmed/31999304
http://dx.doi.org/10.1084/jem.20182091

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