Mutation position is an important determinant for predicting cancer neoantigens

Tumor-specific mutations can generate neoantigens that drive CD8 T cell responses against cancer. Next-generation sequencing and computational methods have been successfully applied to identify mutations and predict neoantigens. However, only a small fraction of predicted neoantigens are immunogenic...

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Detalles Bibliográficos
Autores principales: Capietto, Aude-Hélène, Jhunjhunwala, Suchit, Pollock, Samuel B., Lupardus, Patrick, Wong, Jim, Hänsch, Lena, Cevallos, James, Chestnut, Yajun, Fernandez, Ajay, Lounsbury, Nicolas, Nozawa, Tamaki, Singh, Manmeet, Fan, Zhiyuan, de la Cruz, Cecile C., Phung, Qui T., Taraborrelli, Lucia, Haley, Benjamin, Lill, Jennie R., Mellman, Ira, Bourgon, Richard, Delamarre, Lélia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144530/
https://www.ncbi.nlm.nih.gov/pubmed/31940002
http://dx.doi.org/10.1084/jem.20190179

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