Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme

Innate mechanisms in the tumor stroma play a crucial role both in the initial rejection of tumors and in cancer promotion. Here, we provide a concise overview of the innate system in cancer and recent advances in the field, including the activation and functions of innate immune cells and the emergi...

Descripción completa

Detalles Bibliográficos
Autores principales: Koliaraki, Vasiliki, Henriques, Ana, Prados, Alejandro, Kollias, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144533/
https://www.ncbi.nlm.nih.gov/pubmed/32044979
http://dx.doi.org/10.1084/jem.20190457
_version_ 1783519852901695488
author Koliaraki, Vasiliki
Henriques, Ana
Prados, Alejandro
Kollias, George
author_facet Koliaraki, Vasiliki
Henriques, Ana
Prados, Alejandro
Kollias, George
author_sort Koliaraki, Vasiliki
collection PubMed
description Innate mechanisms in the tumor stroma play a crucial role both in the initial rejection of tumors and in cancer promotion. Here, we provide a concise overview of the innate system in cancer and recent advances in the field, including the activation and functions of innate immune cells and the emerging innate properties and modulatory roles of the fibroblastic mesenchyme. Novel insights into the diverse identities and functions of the innate immune and mesenchymal cells in the microenvironment of tumors should lead to improved anticancer therapies.
format Online
Article
Text
id pubmed-7144533
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-71445332020-10-06 Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme Koliaraki, Vasiliki Henriques, Ana Prados, Alejandro Kollias, George J Exp Med Review Innate mechanisms in the tumor stroma play a crucial role both in the initial rejection of tumors and in cancer promotion. Here, we provide a concise overview of the innate system in cancer and recent advances in the field, including the activation and functions of innate immune cells and the emerging innate properties and modulatory roles of the fibroblastic mesenchyme. Novel insights into the diverse identities and functions of the innate immune and mesenchymal cells in the microenvironment of tumors should lead to improved anticancer therapies. Rockefeller University Press 2020-02-11 /pmc/articles/PMC7144533/ /pubmed/32044979 http://dx.doi.org/10.1084/jem.20190457 Text en © 2020 Koliaraki et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Review
Koliaraki, Vasiliki
Henriques, Ana
Prados, Alejandro
Kollias, George
Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
title Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
title_full Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
title_fullStr Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
title_full_unstemmed Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
title_short Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme
title_sort unfolding innate mechanisms in the cancer microenvironment: the emerging role of the mesenchyme
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144533/
https://www.ncbi.nlm.nih.gov/pubmed/32044979
http://dx.doi.org/10.1084/jem.20190457
work_keys_str_mv AT koliarakivasiliki unfoldinginnatemechanismsinthecancermicroenvironmenttheemergingroleofthemesenchyme
AT henriquesana unfoldinginnatemechanismsinthecancermicroenvironmenttheemergingroleofthemesenchyme
AT pradosalejandro unfoldinginnatemechanismsinthecancermicroenvironmenttheemergingroleofthemesenchyme
AT kolliasgeorge unfoldinginnatemechanismsinthecancermicroenvironmenttheemergingroleofthemesenchyme

Ejemplares similares